Evidence map›Paper›PMID 28503085›Full record

ArticleJournal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology2017

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R.

Anna Niescioruk, Dorota Nieciecka, Anna K Puszko, Agata Królikowska, Piotr Kosson, Gerard Y Perret, Pawel Krysinski, Aleksandra Misicka

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anna NiesciorukFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Dorota NiecieckaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Anna K PuszkoFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Agata KrólikowskaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Piotr KossonDepartment of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Gerard Y PerretSorbonne Paris Cité, Université Paris 13, INSERM U1125, 74 rue Marcel Cachin, 93017 Bobigny, France.
Pawel KrysinskiFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Aleksandra MisickaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
University of Warsaw · PLMossakowski Medical Research Institute, Polish Academy of Sciences · PLSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Superparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as targeted drug delivery vehicles, because they can be guided to their target with the help of an external magnetic field. Functionalization of nanoparticles' surface with molecules, which bind with high affinity to receptors on target tissue significantly facilitates delivery of coated nanoparticles to their targeted site. Here, we demonstrate conjugation of an antiangiogenic and antitumor peptide ATWLPPR (A7R) to SPIONs modified with sebacic acid (SPIONs-SA). Successful conjugation was confirmed by various analytical techniques (FTIR, SERS, SEM-EDS, TEM, TGA). Cell cytotoxicity studies, against two cell lines (HUVEC and MDA-MB-231) indicated that SPIONs modified with A7R reduced HUVEC cell viability at concentrations higher than 0.01 mg Fe/mL, in comparison to cells that were exposed to either the nanoparticles modified with sebacic acid or A7R peptide solely, what might be partially caused by a process of internalization.

Indexed as

A7R peptideAngiogenesisHealth effectsNeuropilin-1SPIONsSuperparamagnetic nanoparticles

Identifiers

PMID28503085
PMCPMC5406482
OpenAlexW2607684901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.