ArticleJournal of muscle research and cell motility1988
Quantification of motility and area changes of Dictyostelium discoideum amoebae in response to chemoattractants.
Article in Journal of muscle research and cell motility, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- Open access microfluidic device for the study of cell migration during chemotaxis.Integrative biology : quantitative biosciences from nano to macro · 2010Article
- Cellular memory: neutrophil orientation reverses during temporally decreasing chemoattractant concentrations.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Chemoattractant-mediated increases in cGMP induce changes in Dictyostelium myosin II heavy chain-specific protein kinase C activities.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report presents quantitative measurements of cell area and motility on the time scale of seconds. The response of Dictyostelium discoideum amoebae to step changes in chemoattractant concentration were followed using an image-processing system. Parameters reflecting total area and motility of several hundred to thousand cells were measured with a time resolution of 2.5 s. Responses of growth phase cells to folate and of starved cells to cAMP were similar. An increase in chemoattractant concentration produced a brief increase in motility followed by a longer-lasting decrease that returned to initial values in 90 s. At high cAMP concentrations the motility remained depressed. Area also increased transiently. Half-maximal responses were produced by 2 nM folate or 2 nM cAMP. Removal of chemoattractant produced a temporary increase in motility and decrease in area. These responses support a model in which antagonistic signals are used to orient cell movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.