ArticleInternal medicine (Tokyo, Japan)2017
Sustained Tubulointerstitial Inflammation in Kidney with Severe Leptospirosis.
Article in Internal medicine (Tokyo, Japan), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Corticosteroids for treatment of leptospirosis.The Cochrane database of systematic reviews · 2025Pooled it
- Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronicInfection and immunity · 2025Article
- Traditional Chinese Medicine and renal regeneration: experimental evidence and future perspectives.Chinese medicine · 2024Review
- Exudative glomerulonephritis associated with acute leptospirosis in dogs.Veterinary pathology · 2024Article
- Implication of the IL-10-Expression Signature in the Pathogenicity ofMicrobiology spectrum · 2022Article
- A multipronged approach for the detection of leptospirosis in captive sloth bears (Melursus ursinus) in Agra and Bannerghatta sloth bear rescue centers in India.The Journal of veterinary medical science · 2021Article
- Clinicopathological factors for tubulointerstitial injury in lupus nephritis.Clinical rheumatology · 2020Article
- The role of macrophages during acute kidney injury: destruction and repair.Pediatric nephrology (Berlin, Germany) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is frequently associated with acute kidney injury. Some survivors are known to progress to chronic kidney disease due to sustained tubulointerstitial inflammation. We present a case of severe leptospirosis with acute renal failure. Although antibiotic therapy resolved the infection, moderate renal dysfunction remained. A renal biopsy demonstrated marked inflammatory infiltration in the tubules and interstitium. Many of the inflammatory cells were CD68-positive monocytes/macrophages, predominantly M1 phenotype. An intermediate dose of oral corticosteroids normalized the patient's serum creatinine levels. We suggest that corticosteroid therapy may be a therapeutic option for some patients with sustained tubulointerstitial nephritis who survive severe leptospirosis.
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