Evidence map›Paper›PMID 28502891›Full record

ReviewCurrent opinion in neurobiology2017

Regulated transport of signaling proteins from synapse to nucleus.

Wendy A Herbst, Kelsey C Martin

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Experience-Regulated Neuronal Signaling in Maternal Behavior.Frontiers in molecular neuroscience · 2022
    Review
  9. Activity-Dependent Gene Expression in Neurons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021
    Review
  10. Article
  11. A Synaptic Framework for the Persistence of Memory Engrams.Frontiers in synaptic neuroscience · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wendy A HerbstDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA; Interdepartmental Program for Neuroscience, University of California, Los Angeles, CA, USA.
Kelsey C MartinDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. Electronic address: kcmartin@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Synapse to Nuclear Signaling During Long-Lasting Neuronal PlasticityR01MH077022 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2007 to 2017
$3.1M
The role of synaptonuclear signaling proteins in long-term hippocampal synaptic plasticityF31MH113310 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HERBST, WENDY · 2017 to 2019
$108k
NIMH NIH HHS F31 MH113310NIMH NIH HHS R01 MH077022
6 · The paper itself

Abstract

Synapse-to-nucleus communication is essential for neural development, plasticity, and repair. In addition to fast electrochemical signaling, neurons employ a slower mechanism of protein transport from synapse-to-nucleus. This mechanism provides potential advantages, including the encoding of spatial information. Many synaptonuclear signaling proteins are transported from the postsynaptic compartment to the nucleus in an activity-dependent manner. The phosphorylation state of two such proteins, CRTC1 and Jacob, is dependent on the stimulus type. While most studies have focused on postsynaptic synaptonuclear communication, a transcriptional co-repressor, CtBP1, was recently discovered to undergo activity-dependent translocation from the presynaptic compartment to the nucleus. Recent evidence indicates that synapse-to-nucleus communication could be cell type-specific, including the identification of a distinct mechanism of excitation-transcription coupling in inhibitory neurons.

Indexed as

Cell NucleusNerve Tissue ProteinsNeuronsProtein TransportSynapsesNerve Tissue Proteins

Identifiers

PMID28502891
PMCPMC5685656
OpenAlexW2613907890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.