Evidence map›Paper›PMID 28502792›Full record

ArticleJournal of molecular biology2017

Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor.

Katy J Sutcliffe, Graeme Henderson, Eamonn Kelly, Richard B Sessions

Open access · hybridAbstract read
In one paragraph

Article in Journal of molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

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  12. Loss of SUR1 subtype KBehavioural brain research · 2021
    Article
  13. Review
  14. Article
  15. Article
  16. G-Protein biased opioid agonists: 3-hydroxy-RSC medicinal chemistry · 2020
    Article
  17. Review
  18. A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Katy J SutcliffeSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK. Electronic address: katy.sutcliffe@bristol.ac.uk.
Graeme HendersonSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.
Eamonn KellySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.
Richard B SessionsSchool of Biochemistry, University of Bristol, Bristol BS8 1TD, UK.
University of Bristol · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J014400/1Medical Research Council MR/J013269/1
6 · The paper itself

Abstract

The μ-opioid receptor (MOPr) is a clinically important G protein-coupled receptor that couples to G

Indexed as

BuprenorphineCell LineDiprenorphineHumansLuminescent MeasurementsMolecular Dynamics SimulationNarcoticsProtein BindingProtein ConformationReceptors, Opioid, muBuprenorphineDiprenorphineNarcoticsnorbuprenorphineReceptors, Opioid, mubuprenorphineG protein-coupled receptormolecular dynamicsμ-opioid receptor

Identifiers

PMID28502792
PMCPMC5472181
OpenAlexW2612269688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.