ArticleCell2017
Metabolic Phenotypes of Response to Vaccination in Humans.
Abstract read
In one paragraph
Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 2 pooled it
21.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
182 citing papers in PubMed, 2 syntheses or guidelines pooled it, 279 citations in OpenAlex.
- Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026Pooled it
- Identification of metabolic signatures of immune response following mRNA and inactivated vaccines against COVID-19: a systematic review.Frontiers in immunology · 2026Pooled it
- The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies.Frontiers in immunology · 2022Trial
- The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination.Cell · 2021Trial
- Tryptophan catabolism reflects disease activity in human tuberculosis.JCI insight · 2020Trial
- Trial
- A Systems Vaccinology Approach Reveals the Mechanisms of Immunogenic Responses to Hantavax Vaccination in Humans.Scientific reports · 2019Trial
- Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.Nature immunology · 2018Trial
- Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling.Redox biology · 2018Trial
- Early antibiotic exposure and vaccine immune responses in preterm infants: potential sex-specific differences.Gut microbes · 2026Observational
- A guide to B cell metabolism.Nature reviews. Immunology · 2026Review
- A targeted metabolic intervention via exercise applied after vaccination shapes kinetics and durability of serum antibody accompanied by a distinct immunometabolic signature: pilot study.Brain, behavior, & immunity - health · 2026Article
- Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals.Vaccines · 2026Article
- Review
- Blood multiomics reveal a dysregulated lipid mediator-mitochondrial network associated with the outcome of advanced cirrhosis.Nature communications · 2026Article
- Multicohort assessment of plasma metabolic signatures of tuberculosis disease in children: a retrospective cross-sectional study.Scientific reports · 2026Article
- Metabolomics in Infectious Diseases and Vaccine Response: Insights into Neglected Tropical and Non-Neglected Pathogens.Infectious disease reports · 2026Review
- Multi-omics Data Integration.Advances in experimental medicine and biology · 2026Review
- Integrative multi-omics analysisiScience · 2025Article
- Systems Biological Analysis of Immune-Metabolic Host Responses to Distinct Malaria Parasites.ACS omega · 2025Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 8 institutions in 2 countries.
Shuzhao LiDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
Nicole L SullivanEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Nadine RouphaelDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA; Hope Clinic of the Emory Vaccine Center, Decatur, GA 30030, USA.
Tianwei YuDepartment of Bioinformatics and Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30030, USA.
Sophia BantonDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
Mohan S MaddurEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Megan McCauslandEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Christopher ChiuEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Jennifer CanniffUniversity of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Sheri DubeyDepartment of Infectious Diseases and Vaccines-West Point, PA, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
Ken LiuDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
ViLinh TranDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
Thomas HaganEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Sai DuraisinghamEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Andreas WielandEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Aneesh K MehtaDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
Jennifer A WhitakerDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
Shankar SubramaniamDepartment of Bioengineering, Department of Chemistry and Biochemistry, Department of Nanoengineering, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Dean P JonesDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA 92037, USA.
Kalpit VoraDepartment of Infectious Diseases and Vaccines-West Point, PA, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
Adriana WeinbergUniversity of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Mark J MulliganDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30303, USA; Hope Clinic of the Emory Vaccine Center, Decatur, GA 30030, USA.
Helder I NakayaSchool of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508, Brazil; Department of Pathology, School of Medicine, Emory University, Atlanta, GA 30329, USA.
Myron LevinUniversity of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Rafi AhmedEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Bali PulendranEmory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology, School of Medicine, Emory University, Atlanta, GA 30329, USA. Electronic address: bpulend@emory.edu.
Emory University · USEmory National Primate Research CenterUniversity of Colorado Anschutz Medical Campus · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USEmory and Henry College · USHOPE Clinic · USLa Jolla Institute for Immunology · USUniversidade de São Paulo · BR
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MVACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7MSystems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0MMOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MUnderstanding the Role of Mucosal Antigen Presenting Cells in Regulating Immune ResponseR37AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2009 to 2018
$4.0MPolarizing T Cell Responses in vivo With Dendritic CellsR37DK057665 · NIDDK · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2010 to 2019
$3.9MPOLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLSR01DK057665 · NIDDK · EMORY UNIVERSITY · PI PULENDRAN, BALI · 2000 to 2009
$3.0MEmory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4MMedical Research Council G0902266NIAID NIH HHS R37 AI048638NIAID NIH HHS R38 AI140299NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI090023NIDDK NIH HHS R01 DK057665NIDDK NIH HHS R37 DK057665NIH HHS P51 OD011132
Abstract
Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Vaccination induces robust antigen-specific antibody, plasmablasts, and CD4
Indexed as
Adaptive ImmunityAdultAgedAgingAntibody FormationCD4-Positive T-LymphocytesFemaleFlow CytometryGene Expression ProfilingGene Regulatory NetworksHerpes Zoster VaccineHumansInositol PhosphatesLongitudinal StudiesMaleMetabolomicsHerpes Zoster VaccineInositol PhosphatesSterolsherpes zoster vaccineimmune responsemetabolomicsmultiscaleshinglessystems biologytranscriptomicsZostavax
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.