Evidence map›Paper›PMID 28502611›Full record

ReviewSeminars in cancer biology2017

Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.

Bhupendra Singh, Josephine S Modica-Napolitano, Keshav K Singh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cancer biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. 3D Printing for Bone-Cartilage Interface Regeneration.Frontiers in bioengineering and biotechnology · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Bhupendra SinghDepartment of Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Josephine S Modica-NapolitanoDepartment of Biology, Merrimack College, North Andover, MA, USA.
Keshav K SinghDepartment of Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Environmental Health, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Aging, University of Alabama at Birmingham, Birmingham, AL, USA; UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA; Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA. Electronic address: kksingh@uab.edu.
Birmingham VA Medical Center · USMerrimack College · USUniversity of Alabama at Birmingham · US

Funding

Mitochondria in Prostate Cancer DiversityR01CA204430 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SINGH, KESHAV K · 2016 to 2020
$1.7M
Mechanisms of arsenic-induced carcinogenesisI01BX001716 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SINGH, KESHAV K · 2014 to 2017
–
BLRD VA I01 BX001716NCI NIH HHS R01 CA204430
6 · The paper itself

Abstract

Mitochondria are complex intracellular organelles that have long been identified as the powerhouses of eukaryotic cells because of the central role they play in oxidative metabolism. A resurgence of interest in the study of mitochondria during the past decade has revealed that mitochondria also play key roles in cell signaling, proliferation, cell metabolism and cell death, and that genetic and/or metabolic alterations in mitochondria contribute to a number of diseases, including cancer. Mitochondria have been identified as signaling organelles, capable of mediating bidirectional intracellular information transfer: anterograde (from nucleus to mitochondria) and retrograde (from mitochondria to nucleus). More recently, evidence is now building that the role of mitochondria extends to intercellular communication as well, and that the mitochondrial genome (mtDNA) and even whole mitochondria are indeed mobile and can mediate information transfer between cells. We define this promiscuous information transfer function of mitochondria and mtDNA as "momiome" to include all mobile functions of mitochondria and the mitochondrial genome. Herein, we review the "momiome" and explore its role in cancer development, progression, and treatment.

Indexed as

Genome, MitochondrialSignal TransductionAnimalsCell CommunicationCell Transformation, NeoplasticDisease SusceptibilityExtracellular SpaceHumansIntracellular SpaceMitochondriaAnterogradeCancerCancer preventionEpigeneticExosomeExtracellular ATPIntercellularMipigeneticsmiRNAMitochondriaMitochondrial DNAMitochondria-to-nucleusNuclear mitochondriaNucleus-to-mitochondriaNumtogenesisRetrogradeTherapy

Identifiers

PMID28502611
PMCPMC5681893
OpenAlexW2612618704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.