ReviewEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2017
Mechanisms underlying the early risk to develop anxiety and depression: A translational approach.
Review in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between brain activity and endogenous and exogenous cortisol - A systematic review.Psychoneuroendocrinology · 2020Pooled it
- A Neurodevelopmental Model of Social Threat Sensitivity as a Mechanism Linking Fearful Temperament, Social Anxiety, and Depression in Youth.Journal of child and adolescent psychopharmacology · 2026Review
- The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life.Developmental science · 2026Article
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025Review
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Structural Brain Imaging Biomarkers of Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- Freud's 1926 conjecture is confirmed: evidence from the dorsal periaqueductal gray in mice that human psychological defense against internal instinctual threat evolved from animal motor defense against external predatory threat.Frontiers in psychology · 2024Review
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Anxiety onset in adolescents: a machine-learning prediction.Molecular psychiatry · 2023Article
- Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure.The American journal of psychiatry · 2022Article
- Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.Biological psychiatry · 2022Article
- Enduring effect of abuse: Childhood maltreatment links to altered theory of mind network among adults.Human brain mapping · 2022Article
- Cross-species anxiety tests in psychiatry: pitfalls and promises.Molecular psychiatry · 2022Review
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- The prefrontal cortex, pathological anxiety, and anxiety disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Measuring Self-Reported Cancer-Related Cognitive Impairment: Recommendations From the Cancer Neuroscience Initiative Working Group.Journal of the National Cancer Institute · 2021Article
- Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.Biological psychiatry · 2021Review
- Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age.Biological psychiatry · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Anxious temperament (AT) is an early life disposition that markedly increases the risk to develop stress related psychopathology such as anxiety and depressive disorders. Since anxiety and depression are common, and frequently have their onset early in life, a better understanding of the factors related to their childhood onset will facilitate the development of new more effective neurally informed interventions. A nonhuman primate (NHP) developmental model of childhood AT has been established, which has provided an understanding of the neural systems and molecular mechanisms mediating the development of AT. Multimodal neuroimaging studies reveal altered brain metabolism across prefrontal, limbic (e.g. central nucleus of the amygdala (Ce) and anterior hippocampus), and brainstem regions, as well as altered functional connectivity involving the Ce. Heritability studies demonstrate that individual variation in AT is heritable, and genetic correlational analyses demonstrate that metabolism in the posterior orbital frontal cortex, the bed nucleus of the stria terminalis, and the periaqueductal gray share a genetic substrate with AT. On a molecular level, the finding of reduced expression of Ce neuroplasticity genes provides the basis for a neurodevelopmental hypothesis focused on the Ce. Viral vector methods for altering gene expression in the Ce of young NHPs are currently being used as a prelude to conceptualizing novel molecularly targeted early life interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.