ArticleThe American journal of pathology2017
Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.
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Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic deletion of miR-200a/200b increases growth and feed conversion efficiency in yellow catfish.Science China. Life sciences · 2026Article
- The Protective Effect of GnRH Agonist Triptorelin on the Histomorphometric Parameters of the Utero-ovarian Tissue in the Doxorubicin- and Cyclophosphamide-treated Mice.Cell biochemistry and biophysics · 2025Article
- Epigenome-wide methylation analysis shows phosphonoethylamine alleviates aberrant DNA methylation in NASH caused by Pcyt2 deficiency.PloS one · 2025Article
- Non-targeted metabolomics and network pharmacology of Taohong Siwu Decoction in hepatic fibrosis mouse model using high resolution mass spectrometry.Frontiers in molecular biosciences · 2025Article
- Article
- Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers.Frontiers in endocrinology · 2023Review
- Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development.Journal of visualized experiments : JoVE · 2022Article
- The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones.Frontiers in immunology · 2022Review
- Mast Cells Induce Ductular Reaction Mimicking Liver Injury in Mice Through Mast Cell-Derived Transforming Growth Factor Beta 1 Signaling.Hepatology (Baltimore, Md.) · 2021Article
- Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2Gene expression · 2020Article
- Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment.The American journal of pathology · 2020Article
- Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.Journal of pineal research · 2020Review
- Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2Biochimica et biophysica acta. Molecular basis of disease · 2019Article
- Possible application of melatonin treatment in human diseases of the biliary tract.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice.Molecular medicine reports · 2019Article
- Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.Hepatology (Baltimore, Md.) · 2019Article
- Mechanisms of cholangiocyte responses to injury.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
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Authors and funding
17 authors at 5 institutions in 2 countries.
Konstantina KyritsiDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas.
Fanyin MengDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas; Department of Research, Central Texas Veterans Health Care System, Temple, Texas; Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas; Research Foundation, Baylor Scott & White Health, Temple, Texas.
Tianhao ZhouDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas.
Nan WuDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas.
Julie VenterDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas.
Heather FrancisDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas; Department of Research, Central Texas Veterans Health Care System, Temple, Texas; Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas.
Lindsey KennedyDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas; Department of Research, Central Texas Veterans Health Care System, Temple, Texas.
Paolo OnoriDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Antonio FranchittoDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy; Eleonora Lorillard Spencer Cenci Foundation, Rome, Italy.
Francesca BernuzziCenter for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy.
Pietro InvernizziCenter for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy.
Kelly McDanielResearch Foundation, Baylor Scott & White Health, Temple, Texas.
Romina MancinelliDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Domenico AlvaroDepartment of Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Eugenio GaudioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Gianfranco AlpiniDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas; Department of Research, Central Texas Veterans Health Care System, Temple, Texas; Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas; Research Foundation, Baylor Scott & White Health, Temple, Texas. Electronic address: galpini@tamu.edu.
Shannon GlaserDepartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas; Department of Research, Central Texas Veterans Health Care System, Temple, Texas; Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas. Electronic address: sglaser@medicine.tamhsc.edu.
Texas A&M Health Science Center · USSapienza University of Rome · ITHumanitas University · ITBaylor Scott & White Health · USIstituto Pasteur · IT
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MMechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–Functional characters of non-coding RNAs in alcoholic liver injuryI01BX001724 · VA · RLR VA MEDICAL CENTER · PI MENG, FANYIN · 2012 to 2024
–Role of Mechanosensitive Receptors During Biliary Proliferation and FibrosisI01BX002192 · VA · OLIN TEAGUE VETERANS CENTER · PI GLASER, SHANNON STROUD · 2014 to 2018
–Autocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX002192BLRD VA I01 BX003031NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959
Abstract
Hepatic fibrosis occurs during the progression of primary sclerosing cholangitis (PSC) and is characterized by accumulation of extracellular matrix proteins. Proliferating cholangiocytes and activated hepatic stellate cells (HSCs) participate in the promotion of liver fibrosis during cholestasis. Gonadotropin-releasing hormone (GnRH) is a trophic peptide hormone synthesized by hypothalamic neurons and the biliary epithelium and exerts its biological effects on cholangiocytes by interaction with the receptor subtype (GnRHR
Indexed as
Gene Expression RegulationAnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCell LineCell ProliferationCholestasisDisease Models, AnimalDisease ProgressionDown-RegulationGonadotropin-Releasing HormoneHepatic Stellate CellsHumansLiverLiver CirrhosisMaleATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BGonadotropin-Releasing HormoneMicroRNAsMirn200 microRNA, mouseMorpholinosReceptors, LHRH
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.