Evidence map›Paper›PMID 28502413›Full record

ArticleRespiratory medicine2017

Understanding the determinants of health-related quality of life in rheumatoid arthritis-associated interstitial lung disease.

Jake G Natalini, Jeff J Swigris, Julie Morisset, Brett M Elicker, Kirk D Jones, Aryeh Fischer, Harold R Collard, Joyce S Lee

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jake G NataliniDepartment of Medicine, University of California, San Francisco, USA.
Jeff J SwigrisDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Julie MorissetDepartment of Medicine, University of California, San Francisco, USA.
Brett M ElickerDepartment of Radiology, University of California, San Francisco, USA.
Kirk D JonesDepartment of Pathology, University of California, San Francisco, USA.
Aryeh FischerDepartment of Medicine, University of Colorado Denver, USA.
Harold R CollardDepartment of Medicine, University of California, San Francisco, USA.
Joyce S LeeDepartment of Medicine, University of Colorado Denver, USA. Electronic address: joyce.lee@ucdenver.edu.

Funding

Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
NCATS NIH HHS KL2 TR000143
6 · The paper itself

Abstract

rationaleHealth-related quality of life (HRQL) is impaired among patients with interstitial lung disease (ILD). Little is understood about HRQL in specific subtypes of ILD.

objectivesThe aim of this study was to characterize and identify clinical determinants of HRQL among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and compare them to patients with idiopathic pulmonary fibrosis (IPF).

methodsWe identified patients with a diagnosis of RA-ILD and IPF from an ongoing longitudinal cohort of ILD patients. HRQL was measured at their baseline visit using the Short Form Health Survey (SF-36), versions 1 and 2. Regression models were used to characterize and understand the relationship between selected baseline clinical covariates, the physical component score (PCS) and mental component score (MCS) of the SF-36. MEASUREMENTS AND MAIN

resultsRA-ILD patients (n = 50) were more likely to be younger and female compared to IPF patients (n = 50). After controlling for age and pulmonary function, RA-ILD patients had a lower HRQL compared to IPF patients, as measured by the PCS (P = 0.03), with significant differences in two of four PCS domains - bodily pain (P < 0.01) and general health (P = 0.01). Clinical covariates most strongly associated with a lower PCS in RA-ILD patients compared to IPF patients were the presence of joint pain or stiffness and dyspnea severity (P < 0.01). Mental and emotional health, as measured by the MCS, was similar between RA-ILD and IPF patients.

conclusionThe physical components of HRQL appear worse in RA-ILD patients compared to IPF patients as measured by the PCS of the SF-36. Differences in the PCS of the SF-36 can be explained in part by dyspnea severity and joint symptoms among patients with RA-ILD.

Indexed as

AgedArthritis, RheumatoidCarbon MonoxideCohort StudiesDyspneaFemaleForced Expiratory VolumeHumansIdiopathic Pulmonary FibrosisLongitudinal StudiesLungLung Diseases, InterstitialMaleMiddle AgedQuality of LifeRespiratory Function TestsCarbon MonoxideIdiopathic pulmonary fibrosisInterstitial lung diseasePainQuality of lifeRheumatoid arthritis

Identifiers

PMID28502413
PMCPMC5486989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.