ArticleThe Journal of physiology2017
The impact of age and frailty on ventricular structure and function in C57BL/6J mice.
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Assessing health in aging male and female mice: does cardiac function dictate frailty or physical resilience?The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Integrating supervised and unsupervised machine learning for behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred mice.bioRxiv : the preprint server for biology · 2026Article
- Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC+/- mice hearts.PloS one · 2026Article
- Gut microbiota metabolism of branched-chain amino acids and their metabolites can improve the physiological function of aging mice.Aging cell · 2025Article
- Simple Method to Isolate Individual Mouse Cardiomyocytes Using Enzymatic Digestion via Retrograde Perfusion.Methods in molecular biology (Clifton, N.J.) · 2025Article
- ImAge quantitates aging and rejuvenation.Nature aging · 2024Article
- Turning back time: effects of young plasma on pan epigenetic clocks and implications for the heart.The journal of cardiovascular aging · 2024Article
- Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation.Research square · 2023Article
- Article
- Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life.GeroScience · 2022Article
- Mechanisms and implications of sex differences in cardiac aging.The journal of cardiovascular aging · 2022Article
- PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging.Aging pathobiology and therapeutics · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Maladaptive Changes Associated With Cardiac Aging Are Sex-Specific and Graded by Frailty and Inflammation in C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Nanoscale Organization, Regulation, and Dynamic Reorganization of Cardiac Calcium Channels.Frontiers in physiology · 2021Review
- Age and life expectancy clocks based on machine learning analysis of mouse frailty.Nature communications · 2020Article
- Article
- Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice.Scientific reports · 2020Article
- Age- and sex-dependent differences in extracellular matrix metabolism associate with cardiac functional and structural changes.Journal of molecular and cellular cardiology · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
key pointsHeart size increases with age (called hypertrophy), and its ability to contract declines. However, these reflect average changes that may not be present, or present to the same extent, in all older individuals. That aging happens at different rates is well accepted clinically. People who are aging rapidly are frail and frailty is measured with a 'frailty index'. We quantified frailty with a validated mouse frailty index tool and evaluated the impacts of age and frailty on cardiac hypertrophy and contractile dysfunction. Hypertrophy increased with age, while contractions, calcium currents and calcium transients declined; these changes were graded by frailty scores. Overall health status, quantified as frailty, may promote maladaptive changes associated with cardiac aging and facilitate the development of diseases such as heart failure. To understand age-related changes in heart structure and function, it is essential to know both chronological age and the health status of the animal. ABSTRACT: On average, cardiac hypertrophy and contractile dysfunction increase with age. Still, individuals age at different rates and their health status varies from fit to frail. We investigated the influence of frailty on age-dependent ventricular remodelling. Frailty was quantified as deficit accumulation in adult (≈7 months) and aged (≈27 months) C57BL/6J mice by adapting a validated frailty index (FI) tool. Hypertrophy and contractile function were evaluated in Langendorff-perfused hearts; cellular correlates/mechanisms were investigated in ventricular myocytes. FI scores increased with age. Mean cardiac hypertrophy increased with age, but values in the adult and aged groups overlapped. When plotted as a function of frailty, hypertrophy was graded by FI score (r = 0.67-0.55, P < 0.0003). Myocyte area also correlated positively with FI (r = 0.34, P = 0.03). Left ventricular developed pressure (LVDP) plus rates of pressure development (+dP/dt) and decay (-dP/dt) declined with age and this was graded by frailty (r = -0.51, P = 0.0007; r = -0.48, P = 0.002; r = -0.56, P = 0.0002 for LVDP, +dP/dt and -dP/dt). Smaller, slower contractions graded by FI score were also seen in ventricular myocytes. Contractile dysfunction in cardiomyocytes isolated from frail mice was attributable to parallel changes in underlying Ca
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