Evidence map›Paper›PMID 28501964›Full record

ArticleAIDS and behavior2018

Consensus statement: Supporting Safer Conception and Pregnancy For Men And Women Living with and Affected by HIV.

Lynn T Matthews, Jolly Beyeza-Kashesya, Ian Cooke, Natasha Davies, Renee Heffron, Angela Kaida, John Kinuthia, Okeoma Mmeje, Augusto E Semprini, Shannon Weber

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  8. "Sexual and reproductive health matters · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 7 countries.

Lynn T MatthewsMGH Global Health and Division of Infectious Diseases, 125 Nashua Street, Suite 722, Boston, MA, 02114, USA. ltmatthews@mgh.harvard.edu.
Jolly Beyeza-KashesyaDepartment of Obstetrics and Gynaecology, Mulago National Referral Hospital, Kampala, Uganda.
Ian CookeUniversity of Sheffield, Sheffield, UK.
Natasha DaviesUniversity of the Witwatersrand, WITS RHI, Johannesburg, South Africa.
Renee HeffronUniversity of Washington, Seattle, USA.
Angela KaidaFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
John KinuthiaUniversity of Washington, Kenyatta National Hospital, University of Nairobi, Nairobi, Kenya.
Okeoma MmejeUniversity of Michigan, Ann Arbor, USA.
Augusto E SempriniUniversity of Milan, Milan, Italy.
Shannon WeberUniversity of California at San Francisco, Zukerberg San Francisco General Hospital, San Francisco, USA.
Kenyatta National Hospital · KEMulago Hospital · UGSan Francisco General Hospital · USSimon Fraser University · CAUniversity of Michigan–Ann Arbor · USUniversity of Milan · ITUniversity of Sheffield · GBUniversity of the Witwatersrand · ZAUniversity of Washington · US

Funding

Periconception HIV risk reduction for HIV-discordant couples in UgandaK23MH095655 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2011 to 2015
$854k
Antiretroviral periconception HIV prevention for HIV discordant couplesR00HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2015 to 2017
$742k
National Institute of Child Health and Human Development R00HD076679National Institute of Mental Health (US) K23MH095655NICHD NIH HHS R00 HD076679NIMH NIH HHS K23 MH095655
6 · The paper itself

Abstract

Safer conception interventions reduce HIV incidence while supporting the reproductive goals of people living with or affected by HIV. We developed a consensus statement to address demand, summarize science, identify information gaps, outline research and policy priorities, and advocate for safer conception services. This statement emerged from a process incorporating consultation from meetings, literature, and key stakeholders. Three co-authors developed an outline which was discussed and modified with co-authors, working group members, and additional clinical, policy, and community experts in safer conception, HIV, and fertility. Co-authors and working group members developed and approved the final manuscript. Consensus across themes of demand, safer conception strategies, and implementation were identified. There is demand for safer conception services. Access is limited by stigma towards PLWH having children and limits to provider knowledge. Efficacy, effectiveness, safety, and acceptability data support a range of safer conception strategies including ART, PrEP, limiting condomless sex to peak fertility, home insemination, male circumcision, STI treatment, couples-based HIV testing, semen processing, and fertility care. Lack of guidelines and training limit implementation. Key outstanding questions within each theme are identified. Consumer demand, scientific data, and global goals to reduce HIV incidence support safer conception service implementation. We recommend that providers offer services to HIV-affected men and women, and program administrators integrate safer conception care into HIV and reproductive health programs. Answers to outstanding questions will refine services but should not hinder steps to empower people to adopt safer conception strategies to meet reproductive goals.

Indexed as

Circumcision, MaleFertilizationHealth Services AccessibilityPre-Exposure ProphylaxisReproductive BehaviorAdultAnti-Retroviral AgentsChildFamily CharacteristicsFemaleFertilityHeterosexualityHIV InfectionsHumansInsemination, ArtificialMaleAnti-Retroviral Agents

Identifiers

PMID28501964
PMCPMC5683943
OpenAlexW2612350005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.