SynthesisArchives of toxicology2017
A primer on systematic reviews in toxicology.
Synthesis in Archives of toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2021Pooled it
- Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review.Scientific reports · 2021Pooled it
- Large scale meta-analysis of preclinical toxicity data for target characterisation and hypotheses generation.PloS one · 2021Pooled it
- Causality analysis of toxicological mechanisms in networked systems such as adverse outcome pathway networks.Archives of toxicology · 2026Review
- Evidence-based AI: from trailblazer to trustblazer?Frontiers in artificial intelligence · 2026Article
- Advances in pharmacokinetic-pharmacodynamic modeling for anesthesia, 1987-2024: a review.Frontiers in pharmacology · 2026Review
- Understanding Target-Specific Effects of Antidepressant Drug Pollution on Molluscs: A Systematic Review Report.Toxics · 2025Review
- Assessing risk of bias in toxicological studies in the era of artificial intelligence.Archives of toxicology · 2025Review
- A systematic scoping review of the neurological effects of COVID-19.Neurotoxicology · 2024Article
- Artificial intelligence (AI)-it's the end of the tox as we know it (and I feel fine).Archives of toxicology · 2024Review
- Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol.Evidence-based toxicology · 2024Article
- Toxic mechanism of the Mongolian medicine "Hunqile-7" based on metabonomics and the metabolism of intestinal flora.Toxicology research · 2023Article
- Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol.PloS one · 2023Article
- The ECOTOXicology Knowledgebase: A Curated Database of Ecologically Relevant Toxicity Tests to Support Environmental Research and Risk Assessment.Environmental toxicology and chemistry · 2022Article
- Biological plausibility in environmental health systematic reviews: a GRADE concept paper.Environment international · 2022Article
- A systematic review on the effects of nanomaterials on gut microbiota.Current research in microbial sciences · 2022Review
- The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review.Environment international · 2022Article
- Review
- Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks.ALTEX · 2022Article
- An interdisciplinary framework for derivation of occupational exposure limits.Frontiers in public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systematic reviews, pioneered in the clinical field, provide a transparent, methodologically rigorous and reproducible means of summarizing the available evidence on a precisely framed research question. Having matured to a well-established approach in many research fields, systematic reviews are receiving increasing attention as a potential tool for answering toxicological questions. In the larger framework of evidence-based toxicology, the advantages and obstacles of, as well as the approaches for, adapting and adopting systematic reviews to toxicology are still being explored. To provide the toxicology community with a starting point for conducting or understanding systematic reviews, we herein summarized available guidance documents from various fields of application. We have elaborated on the systematic review process by breaking it down into ten steps, starting with planning the project, framing the question, and writing and publishing the protocol, and concluding with interpretation and reporting. In addition, we have identified the specific methodological challenges of toxicological questions and have summarized how these can be addressed. Ultimately, this primer is intended to stimulate scientific discussions of the identified issues to fuel the development of toxicology-specific methodology and to encourage the application of systematic review methodology to toxicological issues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.