ArticleMycopathologia2017
Role of the Inositol Polyphosphate Multikinase Ipk2 in Regulation of Hyphal Development, Calcium Signaling and Secretion in Candida albicans.
Article in Mycopathologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IPACS infectious diseases · 2025Article
- Arg1 frommBio · 2024Article
- TNP Analogues Inhibit the Virulence Promoting IPBiomolecules · 2022Article
- Inositol polyphosphate-protein interactions: Implications for microbial pathogenicity.Cellular microbiology · 2021Review
- IPmBio · 2020Article
- Rice EARLY SENESCENCE 2, encoding an inositol polyphosphate kinase, is involved in leaf senescence.BMC plant biology · 2020Article
- Integrated proteomic and metabolomic analysis to study the effects of spaceflight on Candida albicans.BMC genomics · 2020Article
- Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity ofFrontiers in cellular and infection microbiology · 2019Review
- Effects of Disruption of PMC1 in the tfp1∆/∆ Mutant on Calcium Homeostasis, Oxidative and Osmotic Stress Resistance in Candida albicans.Mycopathologia · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inositol polyphosphates are a family of inositol derivatives and ubiquitously distributed in various organisms. Their generation is catalyzed by inositol polyphosphate multikinases, which play essential roles in abundant cellular processes. However, little is known about the kinds and functions of inositol polyphosphate multikinases in the important fungal pathogen, C. albicans. In this study, we identified a C. albicans inositol polyphosphate multikinase, Ipk2. This kinase shares the conserved IPK domain and localizes in the nucleus. A strain with controllable expression of IPK2 was constructed using the inducible promoter of MET3. Down-regulation of IPK2 by addition of methionine and cysteine enhanced the ability of hyphal development, increased expression of hypha-specific genes and promoted transport of hypha-specific factors. Moreover, this down-regulation rendered increase in cytoplasmic calcium levels but decrease in cellular total calcium contents, indicating its role in regulation of calcium homeostasis. Assays of secretion and macrophage killing further demonstrated that Ipk2 negatively regulated secretion of degradative enzymes and damage to macrophages. This study sheds a novel light on the functions of inositol polyphosphate multikinases in fungal organisms.
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