ArticleThe EMBO journal1988
Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 342 citations in OpenAlex.
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- The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)-Implications for Parkinson's Disease and Rett Syndrome.Molecular neurobiology · 2024Article
- Characterization of Cerebellum-Specific Ribosomal DNA Epigenetic Modifications in Alzheimer's Disease: Should the Cerebellum Serve as a Control Tissue After All?Molecular neurobiology · 2020Article
- The sense behind retroviral anti-sense transcription.Virology journal · 2017Article
- The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.Frontiers in molecular neuroscience · 2017Review
- Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia.Stress (Amsterdam, Netherlands) · 2014Article
- A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis.PloS one · 2013Article
- Down-regulation of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human gastric cancer cells.PloS one · 2012Article
- Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.Molecular & cellular proteomics : MCP · 2009Article
- Furan-modified oligonucleotides for fast, high-yielding and site-selective DNA inter-strand cross-linking with non-modified complements.Nucleic acids research · 2009Article
- Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.Brain research. Molecular brain research · 2003Article
- Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements.The Biochemical journal · 2001Article
- The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth.Molecular and cellular biochemistry · 2000Review
- Intracellular modulation of NMDA receptor function by antipsychotic drugs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells.The Biochemical journal · 2000Article
- The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.Molecular and cellular biology · 1999Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthesis of the endogenous opioid precursor, proenkephalin, is regulated by neurotransmitters and membrane depolarization. These events act through second messenger dependent signal transduction pathways via a short inducible DNA enhancer to regulate transcription of the proenkephalin gene. Two DNA elements located within this enhancer are essential for the transcriptional response to cAMP and phorbol ester. Inactivation of either element by mutation or by alteration of their stereospecific alignment eliminates inducible enhancer activity. The promoter distal element, ENKCRE-1, in the absence of a functional adjacent ENKCRE-2 element, has no inherent capacity to activate transcription. However, in the presence of a functional ENKCRE-2 element, this element synergistically augments cAMP and phorbol ester inducible transcription. The promoter proximal element, ENKCRE-2, is essential for both basal and regulated enhancer function. Four different protein factors found in HeLa cell nuclear extracts bind in vitro to the enhancer region. ENKTF-1, a novel enhancer binding protein, binds to the DNA region encompassing ENKCRE-1. The transcription factors AP-1 and AP-4 bind to overlapping sites spanning ENKCRE-2, and a fourth transcription factor, AP-2, binds to a site immediately downstream of ENKCRE-2. The binding of ENKTF-1 to mutant ENKCRE-1 sequences in vitro correlates with the in vivo inducibility of the mutant elements suggesting that ENKTF-1 acts in combination with factors that recognize the ENKCRE-2 domain to regulate cAMP inducible transcription. Together, the two DNA elements, ENKCRE-1 and ENKCRE-2 and the protein factors with which they interact, play a critical role in the transduction and reception of signals transmitted from cell surface receptors to the proenkephalin nuclear transcription complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.