Evidence map›Paper›PMID 28501678›Full record

ArticleThrombosis research2017

The risk of venous thromboembolism with aspirin compared to anticoagulants after hip and knee arthroplasty.

Janet N Chu, Judith Maselli, Andrew D Auerbach, Margaret C Fang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Janet N ChuDepartment of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Judith MaselliDivision of Hospital Medicine, University of California, San Francisco, San Francisco, CA, United States.
Andrew D AuerbachDivision of Hospital Medicine, University of California, San Francisco, San Francisco, CA, United States.
Margaret C FangDivision of Hospital Medicine, University of California, San Francisco, San Francisco, CA, United States. Electronic address: Margaret.Fang@ucsf.edu.
University of California, San Francisco · US

Funding

Anticoagulation Treatment and Long-Term Outcomes After Venous ThromboembolismR01HL103820 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FANG, MARGARET C. · 2010 to 2014
$3.6M
NHLBI NIH HHS R01 HL103820
6 · The paper itself

Abstract

backgroundRecent guidelines include aspirin as an option to prevent venous thromboembolism (VTE) in selected patients undergoing hip or knee replacement surgery. However, the efficacy of aspirin after arthroplasty has not been well-defined, particularly in more contemporary patient populations. We compared rates of post-operative VTE between patients who received aspirin-only versus anticoagulants after hip or knee arthroplasty, using data from a large US-based administrative database. MATERIALS AND

methodsWe conducted a retrospective cohort study of 231,780 adults who underwent total knee arthroplasty and 110,621 who underwent total hip arthroplasty in 2009-2012 and who received pharmacologic VTE prophylaxis (aspirin or anticoagulant) within the first 7days after surgery. We compared the risk of post-operative VTE between patients receiving aspirin-only vs. anticoagulants, controlling for clinical and hospital characteristics using multivariable logistic regression with propensity score adjustment.

resultsAspirin-only prophylaxis was administered to 7.5% of patients after knee arthroplasty and 8.0% after hip arthroplasty. Post-operative VTE was diagnosed in 2217 (0.96%) patients after knee arthroplasty and 454 (0.41%) after hip arthroplasty. Compared to anticoagulants, aspirin was not associated with a higher risk for post-operative VTE either after knee arthroplasty (adjusted odds ratio and 95% confidence interval [OR] 0.34 [0.24-0.48]) or hip arthroplasty (OR 0.82 [0.45-1.51]).

conclusionsAspirin was uncommonly administered as the sole prophylactic agent after hip or knee arthroplasty in this study. However, patients who received aspirin-only had similar rates of post-operative VTE compared to patients who received anticoagulants. Further research should focus on distinguishing which patients benefit more from anticoagulants versus aspirin after arthroplasty.

Indexed as

AdolescentAdultAgedAged, 80 and overAnticoagulantsArthroplasty, Replacement, HipArthroplasty, Replacement, KneeAspirinFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioPlatelet Aggregation InhibitorsPostoperative ComplicationsAnticoagulantsAspirinPlatelet Aggregation InhibitorsAnticoagulantsArthroplastyAspirinPreventionVenous thromboembolism

Identifiers

PMID28501678
PMCPMC5531185
OpenAlexW2605963556

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.