Evidence map›Paper›PMID 28501654›Full record

ArticleEnvironmental research2017

Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age: The home study.

Marisa E Millenson, Joseph M Braun, Antonia M Calafat, Dana Boyd Barr, Yen-Tsung Huang, Aimin Chen, Bruce P Lanphear, Kimberly Yolton

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00129324 (Neurobehavioral Effects of Prevalent Neurotoxicants in Children), which is not on this map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
11.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00129324 nacompletednot on this map

Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health

TypeinterventionalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran2003 to 2018Enrolled468ConditionsEnvironmental Exposures, Child Development, Lead and Injury ReductionArmsLead Hazard Control Intervention, Injury Hazard Control Intervention
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Review
  9. Review
  10. Endocrine Disruptor Chemicals and Children's Health.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Endocrine-disrupting chemicals: implications for human health.The lancet. Diabetes & endocrinology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Marisa E MillensonDepartment of Epidemiology, Brown University, Providence, RI 02912, USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI 02912, USA. Electronic address: joseph_braun_1@brown.edu.
Antonia M CalafatDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Dana Boyd BarrDepartment of Environmental Health, Emory University, Atlanta, GA, USA.
Yen-Tsung HuangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Aimin ChenDepartment of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
Bruce P LanphearFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Brown University · USCenters for Disease Control and Prevention · USCincinnati Children's Hospital Medical Center · USEmory University · USInstitute of Statistical Science, Academia Sinica · TWSimon Fraser University · CAUniversity of Cincinnati · US

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
A Community-Based Trial to Prevent Lead Poisoning and InjuriesR01ES014575 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2007 to 2011
$2.9M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child NeurobehaviorR01ES024381 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2015 to 2018
$2.4M
Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early ChildhoodR01ES015517 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2009 to 2010
$1.5M
Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic BehaviorsR00ES020346 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2013 to 2015
$683k
NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R00 ES020346NIEHS NIH HHS R01 ES014575NIEHS NIH HHS R01 ES015517NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES024381
6 · The paper itself

Abstract

backgroundPrenatal exposure to organophosphate insecticides may be associated with autism spectrum disorders and related behaviors. This association may be modified by single nucleotide polymorphisms in the paraoxonase (PON1) enzyme.

objectiveWe examined the relationship of prenatal organophosphate insecticide biomarkers with reciprocal social, repetitive, and stereotypic behaviors in 8-year old children, and modification of this relationship by child PON1 polymorphisms.

methodsAmong 224 pregnant women, we quantified concentrations of six nonspecific dialkyl phosphate (DAP) metabolites of organophosphate insecticides in two urine samples collected at ~16 and ~26 weeks gestation. When children were eight years old, we administered the Social Responsiveness Scale (SRS), a continuous measure of various dimensions of interpersonal behavior, communication, and repetitive/stereotypic behaviors. We estimated the association between a 10-fold increase in the sum of six DAP concentrations (ΣDAP) and SRS scores. We examined whether child PON1

resultsAfter covariate adjustment, ΣDAP concentrations were not associated with SRS scores [β=-1.2; 95% confidence interval (CI): -4.0, 1.6]. Among children with the PON1

conclusionsIn this cohort, prenatal urinary DAP concentrations were not associated with children's social behaviors; these associations were not modified by child PON1 genotype.

Indexed as

Maternal ExposureAryldialkylphosphataseAutism Spectrum DisorderBiomarkersChildCohort StudiesFemaleHumansInsecticidesMaleOhioOrganophosphorus CompoundsPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsProspective StudiesAryldialkylphosphataseBiomarkersInsecticidesOrganophosphorus CompoundsPON1 protein, humanAnd neurodevelopmentAutism spectrum disordersChildrenInsecticidesPrenatal

Identifiers

PMID28501654
PMCPMC5506847
OpenAlexW2613864578

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.