ArticleTicks and tick-borne diseases2017
Transmission of Borrelia miyamotoi sensu lato relapsing fever group spirochetes in relation to duration of attachment by Ixodes scapularis nymphs.
Article in Ticks and tick-borne diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- The Lyme Disease Vaccine Paradox.Journal of clinical medicine · 2026Article
- Occurrence of Borrelia miyamotoi in Ixodes ricinus and Dermacentor reticulatus ticks removed from human skin in Poland in 2022-2024.Scientific reports · 2026Article
- Establishment of a laboratory mouse model to studyFrontiers in immunology · 2026Article
- Fipronil prevents transmission of Lyme disease spirochetes.Parasitology · 2024Article
- Early transcriptomic changes at the skin interface during Powassan virus transmission byFrontiers in immunology · 2024Article
- Tick-Borne Co-Infections: Challenges in Molecular and Serologic Diagnoses.Pathogens (Basel, Switzerland) · 2023Review
- The Lone Star tick, Amblyomma americanum, salivary factors exacerbate the clinical outcome of Heartland virus disease in a small animal model.Scientific reports · 2023Article
- A serological assay to detect and differentiate rodent exposure to soft tick and hard tick relapsing fever infections in the United States.Ticks and tick-borne diseases · 2023Article
- The Lone Star Tick, Amblyomma americanum, salivary factors exacerbate the clinical outcome of Heartland virus disease in a small animal model.Research square · 2023Article
- Review
- Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand.PLoS neglected tropical diseases · 2023Article
- Case report: First case ofIDCases · 2023Article
- Transmission Cycle of Tick-Borne Infections and Co-Infections, Animal Models and Diseases.Pathogens (Basel, Switzerland) · 2022Review
- A comparison of horizontal and transovarial transmission efficiency of Borrelia miyamotoi by Ixodes scapularis.Ticks and tick-borne diseases · 2022Article
- The raccoon dog (International journal for parasitology. Parasites and wildlife · 2021Article
- Long-term study of Borrelia and Babesia prevalence and co-infection in Ixodes ricinus and Dermacentor recticulatus ticks removed from humans in Poland, 2016-2019.Parasites & vectors · 2021Article
- Isolation of Borrelia miyamotoi and other Borreliae using a modified BSK medium.Scientific reports · 2021Article
- Induced Transient Immune Tolerance in Ticks and Vertebrate Host: A Keystone of Tick-Borne Diseases?Frontiers in immunology · 2021Review
- Pathogenesis of Relapsing Fever.Current issues in molecular biology · 2021Review
- Lyme Disease: Diversity ofHealthcare (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Borrelia miyamotoi sensu lato relapsing fever group spirochetes are emerging as causative agents of human illness (Borrelia miyamotoi disease) in the United States. Host-seeking Ixodes scapularis ticks are naturally infected with these spirochetes in the eastern United States and experimentally capable of transmitting B. miyamotoi. However, the duration of time required from tick attachment to spirochete transmission has yet to be determined. We therefore conducted a study to assess spirochete transmission by single transovarially infected I. scapularis nymphs to outbred white mice at three time points post-attachment (24, 48, and 72h) and for a complete feed (>72-96h). Based on detection of B. miyamotoi DNA from the blood of mice fed on by an infected nymph, the probability of spirochete transmission increased from 10% by 24h of attachment (evidence of infection in 3/30 mice) to 31% by 48h (11/35 mice), 63% by 72h (22/35 mice), and 73% for a complete feed (22/30 mice). We conclude that (i) single I. scapularis nymphs effectively transmit B. miyamotoi relapsing fever group spirochetes while feeding, (ii) transmission can occur within the first 24h of nymphal attachment, and (iii) the probability of transmission increases with the duration of nymphal attachment.
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