ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2017
The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle.
Renee Margossian, Victor Zak, Amanda J Shillingford, Anthony M Hlavacek, James F Cnota, Michael D Puchalski, Jami C Levine, Brian W McCrindle, Meryl S Cohen, Karen Altmann and 4 more
Abstract readMulticenter Study
In one paragraphArticle in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors at 11 institutions in 2 countries.
Renee MargossianBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: renee.margossian@cardio.chboston.org.
Victor ZakNew England Research Institutes, Watertown, Massachusetts.
Amanda J ShillingfordMedical College of Wisconsin, Milwaukee, Wisconsin.
Anthony M HlavacekMedical University of South Carolina, Charleston, South Carolina.
James F CnotaCincinnati Children's Hospital, Cincinnati, Ohio.
Michael D PuchalskiUniversity of Utah, Salt Lake City, Utah.
Jami C LevineBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Brian W McCrindleThe Hospital for Sick Children, Toronto, Ontario, Canada.
Meryl S CohenThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Karen AltmannColumbia University, New York, New York.
Piers C BarkerDuke University Medical Center, Durham, North Carolina.
Daphne T HsuColumbia University, New York, New York.
Steven D ColanBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts; New England Research Institutes, Watertown, Massachusetts.
Pediatric Heart Network Investigators
Columbia University · USHarvard University · USBoston Children's Hospital · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USDuke Medical Center · USHospital for Sick Children · CAMedical College of Wisconsin · USMedical University of South Carolina · USNew England Research Institutes · USUniversity of Utah · US
Funding
Pediatric Heart network DCCU10HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2011 to 2016
$44.9MVentricular Volumes and Varability (VVV)U01HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI SLEEPER, LYNN A · 2001 to 2010
$40.3MMIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C ProgramU24HL135691 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2017 to 2024
$37.9MPediatric Heart Network: Follow-up of the Single Ventricle Reconstruction TrialU01HL068290 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAI, WYMAN W · 2001 to 2010
$4.1MPediatric Heart Disease Network: CHOP MembershipU01HL068279 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI VETTER, VICTORIA L · 2001 to 2010
$3.7MRandomized Therapeutic Trials in Pediatric Heart DiseaseU01HL068285 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 2001 to 2010
$3.4MRandomized Clinical Trials for Pediatric Heart DiseaseU01HL068281 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAUL, J PHILIP · 2001 to 2010
$3.2MClinical and genomic responses to remote ischemic preconditioningU01HL068288 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W · 2001 to 2010
$3.0MIntermountain Pediatric Heart Disease Research CenterU01HL068292 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN · 2001 to 2010
$2.7MThe Duke-UNC-CH Pediatric Cardiology Clinical CenterU01HL068269 · NHLBI · DUKE UNIVERSITY · PI LI, JENNIFER S · 2001 to 2010
$2.6MPediatric Heart Network Prairieland ConsortiumUG1HL135678 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, PAYNE, RONALD MARK · 2017 to 2023
$2.4MPediatric Heart Network - Utah CenterUG1HL135646 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2017 to 2023
$2.3MNHLBI NIH HHS U01 HL068269NHLBI NIH HHS U01 HL068270NHLBI NIH HHS U01 HL068279NHLBI NIH HHS U01 HL068281NHLBI NIH HHS U01 HL068285NHLBI NIH HHS U01 HL068288NHLBI NIH HHS U01 HL068290NHLBI NIH HHS U01 HL068292NHLBI NIH HHS U01 HL085057NHLBI NIH HHS U10 HL068270NHLBI NIH HHS U24 HL135691NHLBI NIH HHS UG1 HL135646NHLBI NIH HHS UG1 HL135678
6 · The paper itselfAbstract
backgroundInfants with single ventricular physiology have volume and pressure overload that adversely affect ventricular mechanics. The impact of superior cavopulmonary anastomosis (SCPA) on single left ventricles versus single right ventricles is not known.
methodsAs part of the Pediatric Heart Network placebo-controlled trial of enalapril in infants with single ventricular physiology, echocardiograms were obtained before SCPA and at 14 months and analyzed in a core laboratory. Retrospective analysis of the following measurements included single ventricular end-diastolic volume (EDV), end-systolic volume (ESV), mass, mass-to-volume ratio (mass/volume), and ejection fraction. Qualitative assessment of atrioventricular valve regurgitation and assessment of diastolic function were also performed.
resultsA total of 156 participants underwent echocardiography at both time points. Before SCPA, mean ESV and mass Z scores were elevated (3.4 ± 3.7 and 4.2 ± 2.9, respectively) as were mean EDV and mass/volume Z scores (2.1 ± 2.5 and 2.0 ± 2.9, respectively). EDV, ESV, and mass decreased after SCPA, but mass/volume and the degree of atrioventricular valve regurgitation did not change. Subjects with morphologic left ventricles demonstrated greater reductions in ventricular volumes and mass than those with right ventricles (mean change in Z score: left ventricular [LV] EDV, -1.9 ± 2.1; right ventricular EDV, -0.7 ± 2.5; LV ESV, -2.3 ± 2.9; right ventricular ESV, -0.9 ± 4.6; LV mass, -2.5 ± 2.8; right ventricular mass, -1.3 ± 2.6; P ≤ .03 for all). Approximately one third of patients whose diastolic function could be assessed had abnormalities at each time point.
conclusionsDecreases in ventricular size and mass occur in patients with single ventricle after SCPA, and the effect is greater in those with LV morphology. The remodeling process resulted in commensurate changes in ventricular mass and volume such that the mass/volume did not change significantly in response to the volume-unloading surgery.
Indexed as
Echocardiography, DopplerFemaleHeart Bypass, RightHeart Defects, CongenitalHeart VentriclesHumansInfantMaleNorth AmericaVentricular RemodelingCongenital heart diseaseDiastolic ventricular functionSingle ventricleSuperior cavopulmonary anastomosisSystolic ventricular functionVentricular remodeling
Identifiers
PMID28501374
PMCPMC5541763
OpenAlexW2613264212
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