Evidence map›Paper›PMID 28500869›Full record

ReviewCurrent opinion in neurobiology2017

To sleep or not to sleep: neuronal and ecological insights.

Ada Eban-Rothschild, William J Giardino, Luis de Lecea

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022
    Review
  17. A Review of Equine Sleep: Implications for Equine Welfare.Frontiers in veterinary science · 2022
    Review
  18. Article
  19. The hypothalamic link between arousal and sleep homeostasis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ada Eban-RothschildDepartment of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA. Electronic address: adae@stanford.edu.
William J GiardinoDepartment of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA.
Luis de LeceaDepartment of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA. Electronic address: llecea@stanford.edu.

Funding

Optogenetic Control of Vigilance State TransitionR01MH087592 · NIMH · STANFORD UNIVERSITY · PI DE LECEA, LUIS · 2010 to 2017
$3.2M
Optogenetic interrogation of sleep circuits during agingR01AG047671 · NIA · STANFORD UNIVERSITY · PI DE LECEA, LUIS, WYSS-CORAY, TONY · 2014 to 2018
$2.1M
Neuronal mapping of anxiety and panicR01MH102638 · NIMH · STANFORD UNIVERSITY · PI DE LECEA, LUIS · 2014 to 2018
$2.0M
Optogenetic studies of hypocretin in binge drinking and negative hedonic valenceF32AA022832 · NIAAA · STANFORD UNIVERSITY · PI GIARDINO, WILLIAM J · 2013 to 2016
$156k
NIAAA NIH HHS F32 AA022832NIA NIH HHS R01 AG047671NIMH NIH HHS R01 MH087592NIMH NIH HHS R01 MH102638
6 · The paper itself

Abstract

Daily, animals need to decide when to stop engaging in cognitive processes and behavioral responses to the environment, and go to sleep. The main processes regulating the daily organization of sleep and wakefulness are circadian rhythms and homeostatic sleep pressure. In addition, motivational processes such as food seeking and predator evasion can modulate sleep/wake behaviors. Here, we discuss the principal processes regulating the propensity to stay awake or go to sleep-focusing on neuronal and behavioral aspects. We first introduce the neuronal populations involved in sleep/wake regulation. Next, we describe the circadian and homeostatic drives for sleep. Then, we highlight studies demonstrating various effects of motivational processes on sleep/wake behaviors, and discuss possible neuronal mechanisms underlying their control.

Indexed as

EnvironmentAnimalsBehavior, AnimalCircadian RhythmHomeostasisNeuronsSleepWakefulness

Identifiers

PMID28500869
PMCPMC5519825

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.