ArticleObesity (Silver Spring, Md.)2017
Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation.
Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Lactoferrin and zinc sulfate supplementation alleviate cisplatin-induced taste disorder: underlying mechanisms via taste and immune modulation.NPJ science of food · 2026Article
- Interactions between taste and oral microbiome: mechanisms and implications for oral and systemic diseases.Journal of oral microbiology · 2026Review
- Toll-like Receptor 4 Differentially Modulates Cardiac Function in Response to Chronic Exposure to High-Fat Diet and Pressure Overload.Nutrients · 2023Article
- Interleukin-6 and tumor necrosis factor-α attenuate dopamine release in mice fed a high-fat diet, but not medium or low-fat diets.Nutritional neuroscience · 2023Article
- TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner.Journal of lipid research · 2023Article
- Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake.International journal of molecular sciences · 2023Review
- Type II taste cells participate in mucosal immune surveillance.PLoS biology · 2023Article
- Brain-derived neurotrophic factor overexpression in taste buds diminishes chemotherapy induced taste loss.The European journal of neuroscience · 2022Article
- Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.Experimental & molecular medicine · 2022Review
- Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.Physiology & behavior · 2022Article
- A nexus of lipid andFrontiers in endocrinology · 2022Review
- Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities.Nature reviews. Endocrinology · 2022Review
- The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review.Frontiers in neuroscience · 2022Review
- Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021Article
- Do Gut Microbes Taste?Nutrients · 2021Review
- To Detect and Reject, Parallel Roles for Taste and Immunity.Current nutrition reports · 2021Review
- Western Diet Induced Remodelling of the Tongue Proteome.Proteomes · 2021Article
- Appetite Regulation of TLR4-Induced Inflammatory Signaling.Frontiers in endocrinology · 2021Review
- Variants in taste genes on caries risk and caries activity status.Medical molecular morphology · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveImmune and inflammatory pathways play important roles in the pathogenesis of metabolic disorders. This study investigated the role of toll-like receptor 4 (TLR4) in orosensory detection of dietary lipids and sugars.
methodsTaste preferences of TLR4 knockout (KO) and wild-type (WT) male mice under a standard and a high-fat, high-sugar diet were assessed with two-bottle tests. Gene expression of taste signaling molecules was analyzed in the tongue epithelium. The role of TLR4 in food intake and weight gain was investigated in TLR4 KO and WT mice fed a high-fat and high-sugar diet for 12 weeks.
resultsCompared to WT mice, TLR4 KO mice showed reduced preference for lipids, sugars, and umami in a two-bottle preference test. The altered taste perception was associated with decreased levels of key taste regulatory molecules in the tongue epithelium. TLR4 KO mice on a high-fat and high-sugar diet consumed less food and drink, resulting in diminished weight gain.
conclusionsTLR4 signaling promotes ingestion of sugar and fat by a mechanism involving increased preference for such obesogenic foods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.