Evidence map›Paper›PMID 28500600›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2017

Comprehensive Assessments of Energy Balance in Mice.

Justin L Grobe

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 47 citations in OpenAlex.

  1. Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.American journal of physiology. Endocrinology and metabolism · 2021
    Trial
  2. Article
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  4. Effect of Calafate (Journal of nutrition and metabolism · 2026
    Article
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  8. Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  9. Early-life sodium restriction programs autonomic dysfunction and salt sensitivity in male C57BL/6J mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  10. Article
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  13. Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
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  18. Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  19. Melanocortin MCPhysiological genomics · 2022
    Article
  20. Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Justin L GrobeDepartment of Pharmacology, Center for Hypertension Research, The Obesity Research and Education Initiative, François M. Abboud Cardiovascular Research Center, The Fraternal Order of Eagles' Diabetes Research Center, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA. justin-grobe@uiowa.edu.
University of Iowa · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL134850
6 · The paper itself

Abstract

Increasing evidence supports a major role for the renin-angiotensin system (RAS) in energy balance physiology. The RAS exists as a circulating system but also as a local paracrine/autocrine signaling mechanism in target tissues including the gastrointestinal tract, the brain, the kidney, and distinct adipose beds. Through activation of various receptors in these target tissues, the RAS contributes to the control of food intake behavior, digestive efficiency, spontaneous physical activity, and aerobic and anaerobic resting metabolism. Although the assortment of methodologies available to assess the various aspects of energy balance can be daunting for an investigator new to this area, a relatively straightforward array of entry-level and advanced methodologies can be employed to comprehensively and quantitatively dissect the effects of experimental manipulations on energy homeostasis. Such methodologies and a simple initial workflow for the use of these methods are described in this chapter, including the use of metabolic caging systems, bomb calorimetry, body composition analyzers, respirometry systems, and direct calorimetry systems. Finally, a brief discussion of the statistical analyses of metabolic data is included.

Indexed as

Energy MetabolismAnimalsBasal MetabolismBody CompositionCalorimetryMiceRenin-Angiotensin SystemAerobicAnaerobicCaloric balanceCalorimetryDigestive efficiencyEnergy balanceEnergy efficiencyMetabolismObesityResting metabolic rate

Identifiers

PMID28500600
PMCPMC5582947
OpenAlexW2612015083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.