Evidence map›Paper›PMID 28500599›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2017

Assessment of the Renin-Angiotensin System in Cellular Organelle: New Arenas for Study in the Mitochondria.

Bryan A Wilson, Mark C Chappell

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bryan A WilsonMcAllister Heart Institute, University of North Caroliina Chapel Hill, Winston-Salem, NC, 27599, USA.
Mark C ChappellHypertension and Vascular Research, Department of Surgery, Cardiovascular Scineces Center, Hanes 6047, Winston-Salem, NC, 27157, USA. mchappel@wakehealth.edu.
Wake Forest University · US

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELL'ITALIA, LOUIS J. · 1994 to 2019
$34.8M
The Impact of Antenatal Steroid Exposure on the Intrarenal Renin-Angiotensin SystP01HD047584 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROSE, JAMES C. · 2005 to 2016
$13.0M
FETAL ENDOCRINE-CARDIOVASCULAR RELATIONSHIPSR01HD017644 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROSE, JAMES C. · 1985 to 2011
$2.8M
Integrative Lipid Metabolism, Inflammation, and Chronic DiseasesT32HL091797 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PARKS, JOHN S · 2008 to 2017
$1.8M
Novel Angiotensin-(1-7) Endopeptidase in Fetal ProgrammingR21HD084227 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, ROSE, JAMES C. · 2016 to 2017
$426k
Establishment of a model for diabetic cardiorenal syndrome in female mRen2.LewisR21HL112237 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, VARAGIC, JASMINA · 2012 to 2013
$398k
NHLBI NIH HHS P01 HL051952NHLBI NIH HHS R21 HL112237NHLBI NIH HHS T32 HL091797NICHD NIH HHS P01 HD047584NICHD NIH HHS R01 HD017644NICHD NIH HHS R21 HD084227
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is an important hormonal system composed of various protein and peptide components that contribute to blood pressure regulation. Although originally characterized as a circulating system, there is increasing evidence for the intracellular expression of RAS elements on the nucleus and mitochondria that may function in concert with or independent of the circulating system. The present chapter describes several experimental approaches to quantify the expression of RAS components in isolated mitochondria from the kidney. These approaches are intended to provide a framework to understand the mitochondrial RAS within a cell-free environment.

Indexed as

Molecular Probe TechniquesAnimalsBlotting, WesternCell-Free SystemFemaleKidneyMaleMitochondriaPeptide FragmentsRenin-Angiotensin SystemSheepPeptide FragmentsAng-(1–7)Ang IIMas proteinMitochondriaNeprilysinPeptide metabolismReninRenin–angiotensin systemSubcellular fractionationThimet oligopeptidase

Identifiers

PMID28500599
PMCPMC9274905
OpenAlexW2613877637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.