ArticleFrontiers of medicine2017
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty.
Article in Frontiers of medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- Optimization and verification of high-fat diet formulation for establishing a rat model of obesity-related precocious puberty.Animal models and experimental medicine · 2026Article
- Preventive Effects ofInternational journal of molecular sciences · 2025Article
- Muricholic acid mediates puberty initiation via the hypothalamic TGR5 signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Early-life gut mycobiome core species modulate metabolic health in mice.Nature communications · 2025Article
- High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation.Frontiers in endocrinology · 2025Article
- Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty.Nutrition & diabetes · 2024Article
- Effects of Liquid Fructose Supplementation and Chronic Unpredictable Stress on Uterine Contractile Activity in Nonpregnant Rats.International journal of molecular sciences · 2024Article
- Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds.BMC medicine · 2023Article
- Effects of high-fat diet and treadmill running on the hypothalamic Kiss-1-GPR54 signaling pathway in male growing rats.Hormones (Athens, Greece) · 2022Article
- LKB1 alleviates high glucose‑ and high fat‑induced inflammation and the expression of GnRH and sexual precocity‑related genes, in mouse hypothalamic cells by activating the AMPK/FOXO1 signaling pathway.Molecular medicine reports · 2022Article
- The impact of BMI on long-term anthropometric and metabolic outcomes in girls with idiopathic central precocious puberty treated with GnRHas.Frontiers in endocrinology · 2022Observational
- Nutritional Regulation of Mammary Tumor Microenvironment.Frontiers in cell and developmental biology · 2022Review
- Influence of HFD-induced precocious puberty on neurodevelopment in mice.Nutrition & metabolism · 2021Article
- Gestational high-fat diet impaired demethylation of Pparα and induced obesity of offspring.Journal of cellular and molecular medicine · 2021Article
- [Association of body fat ratio with precocious puberty in girls].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Diabetic vasculopathy: macro and microvascular injury.Current pathobiology reports · 2020Article
- Microbial Reconstitution Reverses Early Female Puberty Induced by Maternal High-fat Diet During Lactation.Endocrinology · 2020Article
- Article
- Postnatal Feeding With a Fat Rich Diet Induces Precocious Puberty Independent of Body Weight, Body Fat, and Leptin Levels in Female Mice.Frontiers in endocrinology · 2019Article
- Effect of High Fructose Corn Syrup (HFCS) Intake on the Female Reproductive Organs and Lipid Accumulation in Adult Rats.Development & reproduction · 2017Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet-induced postnatal childhood obesity and puberty.
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