Observational studyBreast cancer research and treatment2017
Childhood and teenage physical activity and breast cancer risk.
Observational study in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical Activity in Cancer Prevention and Survival: A Systematic Review.Medicine and science in sports and exercise · 2019Pooled it
- Childhood and Adolescent Factors and Thyroid Cancer Incidence in Adult Women in the Sister Study Cohort.Cancer causes & control : CCC · 2026Article
- Modifiable and Nonmodifiable Risk Factors for Breast Cancer: A Comprehensive Scoping Review.International journal of breast cancer · 2026Review
- The Influence of the COVID-19 Pandemic on Small Business Support for Youth Physical Activity Opportunities in Urban, Low-Income, Predominantly Black Neighborhoods.Journal of racial and ethnic health disparities · 2025Article
- Article
- Outcomes of physical exercises on initiation, progression, and treatment of breast cancer.Cell communication and signaling : CCS · 2024Review
- Identification of distinct physical activity profiles through adolescence: a longitudinal qualitative description study.Frontiers in sports and active living · 2024Article
- Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science.Cold Spring Harbor perspectives in medicine · 2023Review
- Physical activity from menarche-to-first pregnancy and risk of breast cancer: the California teachers study.Cancer causes & control : CCC · 2022Article
- Neighborhood Contexts and Breast Cancer Among Asian American Women.Journal of immigrant and minority health · 2022Article
- Early life physical activity and risk of ovarian cancer in adulthood.International journal of cancer · 2021Article
- Review
- Physical Activity and Breast Cancer: Focusing on High-Risk Subgroups and Putting Recommendations in Context.Cancer research · 2020Article
- Recreational Physical Activity Is Associated with Reduced Breast Cancer Risk in Adult Women at High Risk for Breast Cancer: A Cohort Study of Women Selected for Familial and Genetic Risk.Cancer research · 2020Article
- Severe acne and risk of breast cancer.Breast cancer research and treatment · 2019Article
- Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.GeroScience · 2019Review
- Adult Physical Activity and Breast Cancer Risk in Women with a Family History of Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Breast Cancer Risk Factors: a Cross- Cultural Comparison between the West and the EastAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Mindfulness in Follow-Up Care After Breast Cancer: Can It Prevent Recurrence?Breast care (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeAdult physical activity is associated with reduced breast cancer risk, but few studies have evaluated activity before adulthood. Early life may be an important period because of rapid breast development and hormonal changes. This study contributes new information by examining childhood (ages 5-12) and teenage (ages 13-19) activity separately and overall.
methodsThe Sister Study is a cohort of 50,884 women aged 35-74. Women reported age 5-19 sports/exercise activities and age 10 and 16 unstructured activities. Both hours and MET-hours of activity were considered in association with breast cancer overall, by ER status, and by menopausal status. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazards models.
results2416 cases were diagnosed during follow-up (mean = 6.4 years). Participation in 7+ hours (vs <1 h) per week of sports/exercise during ages 5-19 was associated with reduced breast cancer risk (HR = 0.75; 95% CI 0.57-0.99). 7+ hours (vs <1 h) per week of unstructured physical activity at age 16, but not age 10, was inversely associated with breast cancer (HR = 0.81; 95% CI 0.70-0.95). Associations were more pronounced for ER+ tumors, especially for activity during the childhood (ages 5-12) period. Due to low correlation between childhood/teenage and adulthood activity in this study (r = 0.1), it is unlikely that recent activity explains our results.
conclusionsFindings from this large cohort indicate higher levels of physical activity during ages 5-19 are inversely associated with breast cancer risk, supporting early life as a window of susceptibility for breast cancer development.
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