Evidence map›Paper›PMID 28500390›Full record

ArticleInternational journal of biometeorology2017

Pollen exposure and hospitalization due to asthma exacerbations: daily time series in a European city.

Nicholas J Osborne, Ian Alcock, Benedict W Wheeler, Shakoor Hajat, Christophe Sarran, Yolanda Clewlow, Rachel N McInnes, Deborah Hemming, Mathew White, Sotiris Vardoulakis and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in International journal of biometeorology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06705764 (Tezepelumab in the Treatment of Emergency Room Asthma in Adults), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06705764 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Tezepelumab in the Treatment of Emergency Room Asthma in Adults (TERAA): A Phase 4 Double-Blinded, Parallel-Group, Randomized Control Trial With an Open Label Extension

TypeinterventionalSponsorUniversity of AlbertaRan2026 to 2026Enrolled100ConditionsSevere AsthmaArmsTezepelumab, Placebo
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. Review
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  12. Observational
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  16. Review
  17. A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen.International journal of environmental research and public health · 2022
    Review
  18. Impact of lockdowns on paediatric asthma hospital presentations over three waves of COVID-19 pandemic.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  19. Review
  20. The Effect of Outdoor Aeroallergens on Asthma Hospitalizations in Children in North-Western Tuscany, Italy.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicholas J OsborneEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK. n.osborne@unsw.edu.au.
Ian AlcockEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.
Benedict W WheelerEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.
Shakoor HajatLondon School of Hygiene and Tropical Medicine, London, UK.
Christophe SarranMet Office Hadley Centre, Fitzroy Road, Exeter, EX1 3PB, UK.
Yolanda ClewlowMet Office Hadley Centre, Fitzroy Road, Exeter, EX1 3PB, UK.
Rachel N McInnesEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.
Deborah HemmingMet Office Hadley Centre, Fitzroy Road, Exeter, EX1 3PB, UK.
Mathew WhiteEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.
Sotiris VardoulakisEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.
Lora E FlemingEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK.

Funding

Medical Research Council MR/K019341/1
6 · The paper itself

Abstract

Exposure to pollen can contribute to increased hospital admissions for asthma exacerbation. This study applied an ecological time series analysis to examine associations between atmospheric concentrations of different pollen types and the risk of hospitalization for asthma in London from 2005 to 2011. The analysis examined short-term associations between daily pollen counts and hospital admissions in the presence of seasonal and long-term patterns, and allowed for time lags between exposure and admission. Models were adjusted for temperature, precipitation, humidity, day of week, and air pollutants. Analyses revealed an association between daily counts (continuous) of grass pollen and adult hospital admissions for asthma in London, with a 4-5-day lag. When grass pollen concentrations were categorized into Met Office pollen 'alert' levels, 'very high' days (vs. 'low') were associated with increased admissions 2-5 days later, peaking at an incidence rate ratio of 1.46 (95%, CI 1.20-1.78) at 3 days. Increased admissions were also associated with 'high' versus 'low' pollen days at a 3-day lag. Results from tree pollen models were inconclusive and likely to have been affected by the shorter pollen seasons and consequent limited number of observation days with higher tree pollen concentrations. Future reductions in asthma hospitalizations may be achieved by better understanding of environmental risks, informing improved alert systems and supporting patients to take preventive measures.

Indexed as

PollenAdolescentAdultAir PollutantsAllergensAsthmaEnvironmental MonitoringHospitalizationHumansLondonMiddle AgedPoaceaeTreesYoung AdultAir PollutantsAllergensAir pollutionAsthmaGrass pollenPollenTime seriesTree pollen

Identifiers

PMID28500390
PMCPMC5643363

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.