Trial reportPsychopharmacology2017
Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders.
Trial report in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00756275 (Varenicline and Motivational Advice for Smokers With SUD), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Varenicline and Motivational Advice for Smokers With SUD
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Cessation classification likelihood increases with higher expired-air carbon monoxide cutoffs: a meta-analysis.Drug and alcohol dependence · 2021Pooled it
- Experimental manipulations of behavioral economic demand for addictive commodities: a meta-analysis.Addiction (Abingdon, England) · 2020Pooled it
- Sensitivity of hypothetical purchase task indices when studying substance use: A systematic literature review.Preventive medicine · 2019Pooled it
- Behavioral economic tobacco demand in relation to cigarette consumption and nicotine dependence: a meta-analysis of cross-sectional relationships.Addiction (Abingdon, England) · 2019Pooled it
- Effects of episodic future thinking on reinforcement pathology during smoking cessation treatment among individuals with substance use disorders.Psychopharmacology · 2022Trial
- The Cigarillo Purchase Task: A Qualitative Analysis.Health behavior research · 2023Article
- Cannabis Use Disorder: A Behavioral Economic Perspective.Current addiction reports · 2022Article
- Effects of acute distress and tobacco cues on tobacco demand.Drug and alcohol dependence · 2021Article
- Behavioral economic measurement of cigarette demand: A descriptive review of published approaches to the cigarette purchase task.Experimental and clinical psychopharmacology · 2020Review
- Behavioral economic demand as a unifying language for addiction science: Promoting collaboration and integration of animal and human models.Experimental and clinical psychopharmacology · 2020Review
- Smoking cessation in inpatient psychiatry treatment facilities: A review.Addictive behaviors reports · 2020Review
- Behavioral economic demand assessments in the addictions.Current opinion in psychology · 2019Review
- Brief Assessment of Cigarette Demand (BACD): Initial development and correlational results in adults and adolescents.Experimental and clinical psychopharmacology · 2019Article
- Examining interrelationships between the Cigarette Purchase Task and delay discounting among pregnant women.Journal of the experimental analysis of behavior · 2019Article
- Validation of a behavioral economic purchase task for assessing drug abuse liability.Addiction biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleCigarette demand is a behavioral economic measure of the relative value of cigarettes. Decreasing the value of cigarette reinforcement may help with quitting smoking.
objectivesThis study aimed to evaluate the effects of initial use of varenicline (VAR) versus nicotine replacement therapy (NRT) on demand for cigarettes on quit day among smokers with substance use disorders (SUD) and to determine whether reduced demand was associated with subsequent abstinence from smoking at 1 and 3 months.
methodsParticipants (N = 110) were randomized to double-blind, double-placebo conditions: VAR with placebo NRT or NRT with placebo capsules. The cigarette purchase task (CPT) was used to assess demand for cigarettes at baseline and on quit day, following a 1-week medication dose run-up/placebo capsule lead-in and first day use of the patch.
resultsDemand for cigarettes decreased from baseline to quit day without significant differences between medications. Reductions in CPT intensity (number of cigarettes that would be smoked if they were free) and CPT breakpoint (lowest price at which no cigarettes would be purchased) predicted greater likelihood of abstaining on quit day. Reduced intensity predicted length of abstinence at 1 and 3 months while reduced breakpoint predicted only 1 month length of abstinence.
conclusionsInitial therapeutic doses of VAR and NRT resulted in similar reductions in cigarette reinforcement. Larger initial reductions in demand on quit day were associated with early success with abstaining from cigarettes. Behavioral economic approaches may be useful for identifying individuals who benefit less from pharmacotherapy and may need additional treatment resources.
trial registrationhttps://clinicaltrials.gov/ct2/show/NCT00756275.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.