ArticleEuropean radiology2017
Evolution of posterior fossa and brain morphology after in utero repair of open neural tube defects assessed by MRI.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- What brain abnormalities can magnetic resonance imaging detect in foetal and early neonatal spina bifida: a systematic review.Neuroradiology · 2022Pooled it
- Open Spinal Dysraphism Without Hindbrain Herniation-Natural History and Postnatal Outcome.Prenatal diagnosis · 2025Article
- Differences between Myeloschisis and Myelomeningocele in Patients Undergoing Prenatal Repair of Open Spina Bifida.Fetal diagnosis and therapy · 2025Article
- Longitudinal MRI in the context of in utero surgery for open spina bifida: A descriptive study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Long-Term Imaging Follow-up from the Management of Myelomeningocele Study.AJNR. American journal of neuroradiology · 2023Article
- The Role of Fetal Brain Magnetic Resonance Imaging in Current Fetal Medicine.Journal of the Belgian Society of Radiology · 2022Article
- Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study.Neuroradiology · 2021Article
- Emerging magnetic resonance imaging techniques in open spina bifida in utero.European radiology experimental · 2021Review
- Imaging of open spinal dysraphisms in the era of prenatal surgery.Pediatric radiology · 2020Review
- Brain abnormalities in myelomeningocele patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Reliability of MR Imaging-Based Posterior Fossa and Brain Stem Measurements in Open Spinal Dysraphism in the Era of Fetal Surgery.AJNR. American journal of neuroradiology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe characteristics of foetuses undergoing in utero repair of open neural tube defects (ONTD) and assess postoperative evolution of posterior fossa and brain morphology.
methodsAnalysis of pre- and postoperative foetal as well as neonatal MRI of 27 foetuses who underwent in utero repair of ONTD. Type and level of ONTD, hindbrain configuration, posterior fossa and liquor space dimensions, and detection of associated findings were compared between MRI studies and to age-matched controls.
resultsLevel of bony spinal defect was defined with exactness of ± one vertebral body. Of surgically confirmed 18 myelomeningoceles (MMC) and 9 myeloschisis (MS), 3 MMC were misdiagnosed as MS due to non-visualisation of a flat membrane on MRI. Hindbrain herniation was more severe in MS than MMC (p < 0.001). After repair, hindbrain herniation resolved in 25/27 cases at 4 weeks and liquor spaces increased. While posterior fossa remained small (p < 0.001), its configuration normalised. Lateral ventricle diameter indexed to cerebral width decreased in 48% and increased in 12% of cases, implying a low rate of progressive obstructive hydrocephalus. Neonatally evident subependymal heterotopias were detected in 33% at preoperative and 50% at postoperative foetal MRI.
conclusionMRI demonstrates change of Chiari malformation type II (CM-II) features. KEY POINTS: • Hindbrain herniation is significantly more pronounced in myeloschisis than in myelomeningocele • Resolution of hindbrain herniation 4 weeks after in utero closure of ONTD • MRI is valuable for preoperative assessment and postoperative evaluation following in utero repair.
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