ArticleScientific reports2017
Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study - findings from Pretest 1 of the German National Cohort.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Characteristics of Respiratory Microbiome in COPD-A Literature Review.Advances in respiratory medicine · 2026Review
- Dysbiosis of the nasal microbiome is associated with prospective acute exacerbation of COPD.Microbiome · 2026Article
- Distinct Nasal Microbiome Profiles and Prediction Model for Allergic Rhinitis, Nonallergic Rhinitis, and Healthy Children.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Pharyngeal Microbiota in Pre-COPD and COPD: Associations with Clinical Pattern and Respiratory Infection.Biomedicines · 2025Article
- Upper respiratory microbial communities of healthy populations are shaped by niche and age.Microbiome · 2024Article
- Human nasal microbiota shifts in healthy and chronic respiratory disease conditions.BMC microbiology · 2024Article
- Upper respiratory microbial communities of healthy populations are shaped by niche and age.bioRxiv : the preprint server for biology · 2024Article
- Characteristics and associations of microbial community in the eye, anterior nares, and oropharynx of healthy adults: eye-nose microbiota transmission.American journal of translational research · 2023Article
- Article
- From the nose to the lungs: the intricate journey of airborne pathogens amid commensal bacteria.American journal of physiology. Cell physiology · 2022Review
- A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants.Infection and immunity · 2022Observational
- Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients.Infection and immunity · 2021Article
- Strategies in Primary Care to Face the SARS-CoV-2 / COVID-19 Pandemic: An Online Survey.Frontiers in medicine · 2021Article
- Nasal microbiome research in ANCA-associated vasculitis: Strengths, limitations, and future directions.Computational and structural biotechnology journal · 2021Review
- 'Self-collected upper respiratory tract swabs for COVID-19 test': A feasible way to increase overall testing rate and conserve resources in South Africa.African journal of primary health care & family medicine · 2020Article
- Oropharyngeal microbiome of a college population following a meningococcal disease outbreak.Scientific reports · 2020Article
- Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.The Journal of allergy and clinical immunology · 2018Article
- Article
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined acceptability, preference and feasibility of collecting nasal and oropharyngeal swabs, followed by microbiome analysis, in a population-based study with 524 participants. Anterior nasal and oropharyngeal swabs were collected by certified personnel. In addition, participants self-collected nasal swabs at home four weeks later. Four swab types were compared regarding (1) participants' satisfaction and acceptance and (2) detection of microbial community structures based on deep sequencing of the 16 S rRNA gene V1-V2 variable regions. All swabbing methods were highly accepted. Microbial community structure analysis revealed 846 phylotypes, 46 of which were unique to oropharynx and 164 unique to nares. The calcium alginate tipped swab was found unsuitable for microbiome determinations. Among the remaining three swab types, there were no differences in oropharyngeal microbiomes detected and only marginal differences in nasal microbiomes. Microbial community structures did not differ between staff-collected and self-collected nasal swabs. These results suggest (1) that nasal and oropharyngeal swabbing are highly feasible methods for human population-based studies that include the characterization of microbial community structures in these important ecological niches, and (2) that self-collection of nasal swabs at home can be used to reduce cost and resources needed, particularly when serial measurements are to be taken.
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