ArticleProceedings of the National Academy of Sciences of the United States of America2017
Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
- Evidence from computational infrared spectroscopy against vibrational detection of propionate by human olfactory receptor OR51E2.European biophysics journal : EBJ · 2026Article
- Non-Markovian Quantum State Diffusion for the tunnelling in SARS-COVID-19 virus.Computational and structural biotechnology journal · 2025Article
- The Luminescence Hypothesis of Olfaction.Sensors (Basel, Switzerland) · 2023Article
- Quantum tunnelling in the context of SARS-CoV-2 infection.Scientific reports · 2022Article
- Sensory Perception of Non-Deuterated and Deuterated Organic Compounds.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Exploring the mechanism of olfactory recognition in the initial stage by modeling the emission spectrum of electron transfer.PloS one · 2020Article
- Elucidation of near-resonance vibronic coherence lifetimes by nonadiabatic electronic-vibrational state character mixing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, an alternative theory concerning the method by which olfactory proteins are activated has garnered attention. This theory proposes that the activation of olfactory G protein-coupled receptors occurs by an inelastic electron tunneling mechanism that is mediated through the presence of an agonist with an appropriate vibrational state to accept the inelastic portion of the tunneling electron's energy. In a recent series of papers, some suggestive theoretical evidence has been offered that this theory may be applied to nonolfactory G protein-coupled receptors (GPCRs), including those associated with the central nervous system (CNS). [Chee HK, June OS (2013)
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