Evidence map›Paper›PMID 28500252›Full record

ArticlePhysiological genomics2017

Transcriptome profiling reveals novel BMI- and sex-specific gene expression signatures for human cardiac hypertrophy.

Mackenzie S Newman, Tina Nguyen, Michael J Watson, Robert W Hull, Han-Gang Yu

Open access · bronzeAbstract read
In one paragraph

Article in Physiological genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. BMPR2 affects valve development via ECM-receptor interaction in zebrafish.Frontiers in cell and developmental biology · 2026
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  9. Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging.American journal of physiology. Heart and circulatory physiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mackenzie S NewmanPhysiology and Pharmacology, West Virginia University, Morgantown, West Virginia.
Tina NguyenPhysiology and Pharmacology, West Virginia University, Morgantown, West Virginia.
Michael J WatsonDepartment of Surgery, Duke University, Durham, North Carolina; and.
Robert W HullDepartment of Cardiology, West Virginia University, Morgantown, West Virginia.
Han-Gang YuPhysiology and Pharmacology, West Virginia University, Morgantown, West Virginia; hyu@hsc.wvu.edu.
West Virginia University · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How obesity or sex may affect the gene expression profiles of human cardiac hypertrophy is unknown. We hypothesized that body-mass index (BMI) and sex can affect gene expression profiles of cardiac hypertrophy. Human heart tissues were grouped according to sex (male, female), BMI (lean<25 kg/m

Indexed as

Body Mass IndexGene Expression ProfilingGene Expression RegulationSex CharacteristicsAdultAgedCardiomegalyCardiomyopathy, DilatedFemaleGene OntologyGene Regulatory NetworksHumansHypertrophy, Left VentricularMaleMiddle AgedMyocardial Ischemiaatrial natriuretic peptide A (NPPA, ANP)brain-type natriuretic peptide B (NPPB, BNP)cardiac hypertrophygene expression signatureheart failureRNA-Seq

Identifiers

PMID28500252
PMCPMC5538878
OpenAlexW2612814210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.