ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Environmental Enrichment Rescues Binocular Matching of Orientation Preference in the Mouse Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Time Window of the Critical Period for Neuroplasticity in S1, V1, and A1 Sensory Areas of Small Rodents: A Systematic Review.Frontiers in neuroanatomy · 2022Pooled it
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- Complex Three-Dimensional Rearing Environments Amplify Compensatory Plasticity Following Early Blindness.eNeuro · 2026Article
- The world through infant eyes: Evidence for the early emergence of the cardinal orientation bias.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multisensory integration, brain plasticity and optogenetics in visual rehabilitation.Frontiers in neurology · 2025Review
- High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7.Neuroscience bulletin · 2024Article
- Widespread and Multifaceted Binocular Integration in the Mouse Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review.Journal of clinical medicine · 2023Review
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- Article
- Neural circuits for binocular vision: Ocular dominance, interocular matching, and disparity selectivity.Frontiers in neural circuits · 2023Review
- Article
- Visual Perceptual Learning Induces Long-Lasting Recovery of Visual Acuity, Visual Depth Perception Abilities and Binocular Matching in Adult Amblyopic Rats.Frontiers in cellular neuroscience · 2022Article
- Lack of Evidence for Stereotypical Direction Columns in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex.Frontiers in cellular neuroscience · 2021Article
- Article
- Review
- Development and binocular matching of orientation selectivity in visual cortex: a computational model.Journal of neurophysiology · 2020Article
- Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.Cell reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Neural circuits are shaped by experience during critical periods of development. Sensory deprivation during these periods permanently compromises an organism's ability to perceive the outside world. In the mouse visual system, normal visual experience during a critical period in early life drives the matching of individual cortical neurons' orientation preferences through the two eyes, likely a key step in the development of binocular vision. Here, in mice of both sexes, we show that the binocular matching process is completely blocked by monocular deprivation spanning the entire critical period. We then show that 3 weeks of environmental enrichment (EE), a paradigm of enhanced sensory, motor, and cognitive stimulation, is sufficient to rescue binocular matching to the level seen in unmanipulated mice. In contrast, 6 weeks of conventional housing only resulted in a partial rescue. Finally, we use two-photon calcium imaging to track the matching process chronically in individual cells during EE-induced rescue. We find that for cells that are clearly dominated by one of the two eyes, the input representing the weaker eye changes its orientation preference to align with that of the dominant eye. These results thus reveal ocular dominance as a key driver of the binocular matching process, and suggest a model whereby the dominant input instructs the development of the weaker input. Such a mechanism may operate in the development of other systems that need to integrate inputs from multiple sources to generate normal neuronal functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.