Evidence map›Paper›PMID 28500216›Full record

Observational studyDiabetes care2017

Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study.

José A Luchsinger, Yong Ma, Costas A Christophi, Hermes Florez, Sherita H Golden, Helen Hazuda, Jill Crandall, Elizabeth Venditti, Karol Watson, Susan Jeffries and 3 more

2 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04841668 completedstarted 2021, after this paper: background citation

Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly

Ran2021Enrolled50Registered outcomes51Posted comparisons0ConditionsType 2 Diabetes MellitusArmsMetformin
PMID 8013758PMID 30397356PMID 16443885PMID 11118008PMID 18220635PMID 12086935PMID 12930161PMID 16219009PMID 11602624PMID 17183300PMID 17350699PMID 17977953other papers from this trial
Open the trial in the graph
NCT03889132 completednot on this mapstarted 2019, after this paper: background citation

Integrated Analysis of the Interactions Between Glycemia and Microbiota Composition, and Their Impact on Brain Iron Deposition and Cognition in Subjects With Obesity

TypeobservationalSponsorInstitut d'Investigació Biomèdica de Girona Dr. Josep TruetaRan2019 to 2025Enrolled128ConditionsObesityArmsBariatric Surgery
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Diabetes-Specific Dementia: A Structured Literature Review of Cognitive Assessment Methods.The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
    Pooled it
  3. Does lifestyle intervention lower clinically significant cognitive impairment risk?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

José A LuchsingerColumbia University Medical Center, New York, NY dppmail@bsc.gwu.edu.
Yong MaBiostatistics Center, The George Washington University, Washington, DC.
Costas A ChristophiBiostatistics Center, The George Washington University, Washington, DC.
Hermes FlorezUniversity of Miami, Miami, FL.
Sherita H GoldenJohns Hopkins University, Baltimore, MD.
Helen HazudaUniversity of Texas Health Science Center, San Antonio, TX.
Jill CrandallAlbert Einstein College of Medicine, Bronx, NY.
Elizabeth VendittiUniversity of Pittsburgh, Pittsburgh, PA.
Karol WatsonUniversity of California, Los Angeles, Los Angeles, CA.
Susan JeffriesUniversity of Pittsburgh, Pittsburgh, PA.
Jennifer J ManlyColumbia University Medical Center, New York, NY.
F Xavier Pi-SunyerColumbia University Medical Center, New York, NY.
Diabetes Prevention Program Research Group
Columbia University Irving Medical Center · USGeorge Washington University · USUniversity of Pittsburgh · USAlbert Einstein College of Medicine · USJohns Hopkins University · USThe University of Texas Health Science Center at San Antonio · USUniversity of California, Los Angeles · USUniversity of Miami · US

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Post-DDP Follow-up StudyU01DK048413 · NIDDK · UNIVERSITY OF WASHINGTON · PI KAHN, STEVEN EMANUEL · 1994 to 2021
$13.7M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048397 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1994 to 2021
$12.0M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048339 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARANETA, MARIA ROSARIO GORREZ, MUDALIAR, SUNDER · 1994 to 2022
$11.4M
NIDDM PRIMARY PREVENTION TRIALU01DK048412 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VENDITTI, ELIZABETH MARY · 1994 to 2021
$11.4M
TITLE OMITTEDU01DK048349 · NIDDK · YESHIVA UNIVERSITY · PI CRANDALL, JILL P · 1994 to 2021
$11.0M
PRIMARY PREVENTION TRIALU01DK048443 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WATSON, KAROL E · 1994 to 2021
$10.2M
Post-DPP Follow-up StudyU01DK048375 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 1994 to 2022
$10.0M
Post-Diabetes Prevention Program (DPP)U01DK048381 · NIDDK · UNIVERSITY OF CHICAGO · PI EHRMANN, DAVID A · 1994 to 2021
$9.6M
NCATS NIH HHS UL1 TR001073NIA NIH HHS K24 AG045334NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK026687NIDDK NIH HHS U01 DK048339NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048380NIDDK NIH HHS U01 DK048381NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048443NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514
6 · The paper itself

Abstract

objectiveWe examined the association of the Diabetes Prevention Program (DPP) intervention arms (lifestyle intervention, metformin, and placebo) with cognition in the Diabetes Prevention Program Outcomes Study (DPPOS). We also examined metformin use, incident type 2 diabetes, and glycemia as exposures. RESEARCH DESIGN AND

methodsThe DPP lasted 2.8 years, followed by a 13-month bridge to DPPOS. Cognition was assessed in DPPOS years 8 and 10 (12 and 14 years after randomization) with the Spanish English Verbal Learning Test (SEVLT), letter fluency and animal fluency tests, Digit Symbol Substitution Test (DSST), and a composite cognitive score.

resultsA total of 2,280 participants (749 lifestyle, 776 metformin, and 755 placebo) aged 63.1 ± 10.7 years underwent cognitive assessments; 67.7% women, 54.6% non-Hispanic white, 20.7% non-Hispanic black, 14.6% Hispanic, 5.5% American Indian, and 4.6% Asian; 26.6% were homozygous or heterozygous for APOE-ε4. At the time of cognitive assessment, type 2 diabetes was higher in the placebo group (57.9%;

conclusionsExposure to intensive lifestyle intervention or metformin was not related to cognition among DPPOS participants. Higher glycemia was related to worse cognitive performance. Metformin seemed cognitively safe among DPPOS participants.

Indexed as

CognitionDiabetes Mellitus, Type 2Life StyleMetforminAgedBlood GlucoseCholesterolEthnicityFemaleFollow-Up StudiesGlycated HemoglobinHumansHypoglycemic AgentsMaleMiddle AgedPolymorphism, Single NucleotideBlood GlucoseCholesterolGlycated HemoglobinHypoglycemic AgentsMetforminTriglycerides

Identifiers

PMID28500216
PMCPMC5481986
OpenAlexW2612859522

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.