Evidence map›Paper›PMID 28500174›Full record

ArticleCirculation. Arrhythmia and electrophysiology2017

Effect of Digoxin Use Among Medicaid Enrollees With Atrial Fibrillation.

Demilade Adedinsewo, Junjun Xu, Pradyumna Agasthi, Adesoji Oderinde, Oluwatoyosi Adekeye, Rajesh Sachdeva, George Rust, Anekwe Onwuanyi

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Demilade AdedinsewoFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
Junjun XuFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
Pradyumna AgasthiFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
Adesoji OderindeFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
Oluwatoyosi AdekeyeFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
Rajesh SachdevaFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
George RustFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.).
Anekwe OnwuanyiFrom the Department of Internal Medicine (D.A., P.A., A.O.), National Center for Primary Care (J.X.), Department of Community Health and Preventive Medicine (O.A.), and Section of Cardiology (R.S., A.O.), Morehouse School of Medicine, Atlanta, GA; Grady Memorial Hospital, Atlanta, GA (D.A., P.A., A.O., R.S., A.O.); and Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee (G.R.). aonwuanyi@msm.edu.
Grady Memorial Hospital · US

Funding

Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
Women's Health Intervention StudyP20MD006881 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI RUST, GEORGE S · 2012 to 2016
$6.0M
Mid-Career Transition -- Mapping Paths to Success in Achieving Community-Level HeK18HS022444 · AHRQ · MOREHOUSE SCHOOL OF MEDICINE · PI RUST, GEORGE S · 2013 to 2014
$532k
AHRQ HHS K18 HS022444NIMHD NIH HHS P20 MD006881NIMHD NIH HHS U54 MD007588
6 · The paper itself

Abstract

backgroundRecently published analysis of contemporary atrial fibrillation (AF) cohorts showed an association between digoxin and increased mortality and hospitalizations; however, other studies have demonstrated conflicting results. Many AF cohort studies did not or were unable to examine racial differences. Our goal was to examine risk factors for hospitalizations and mortality with digoxin use in a diverse real-world AF patient population and evaluate racial differences. METHODS AND

resultsWe performed a retrospective cohort analysis of claims data for Medicaid beneficiaries, aged 18 to 64 years, with incident diagnosis of AF in 2008 with follow-up until December 31, 2009. We created Kaplan-Meier curves and constructed multivariable Cox proportional hazard models for mortality and hospitalization. We identified 11 297 patients with an incident diagnosis of AF in 2008, of those, 1401 (12.4%) were on digoxin. Kaplan-Meier analysis demonstrated an increased risk of hospitalization with digoxin use overall and within race and heart failure groups. In adjusted models, digoxin was associated with an increased risk of hospitalization (adjusted hazard ratio, 1.54; 95% confidence interval, 1.39-1.70) and mortality (adjusted hazard ratio, 1.50; 95% confidence interval, 1.05-2.13). Overall, blacks had a higher risk of hospitalization but similar mortality when compared with whites regardless of digoxin use. We found no significant interaction between race and digoxin use for mortality (

conclusionsOur study demonstrates an overall increased risk of hospitalizations and mortality with digoxin use but no racial/ethnic differences in outcomes were observed. Further studies including minority populations are needed to critically evaluate these associations.

Indexed as

MedicaidAdministrative Claims, HealthcareAdolescentAdultAnti-Arrhythmia AgentsAtrial FibrillationBlack or African AmericanChi-Square DistributionDigoxinDisease ProgressionDrug Utilization ReviewFemaleHeart FailureHospitalizationHumansIncidenceAnti-Arrhythmia AgentsDigoxinatrial fibrillationdigoxinheart failurehospitalizationMedicaid

Identifiers

PMID28500174
PMCPMC5522586
OpenAlexW2612337111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.