Evidence map›Paper›PMID 28500072›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

The Upregulation of Integrin α

Moammir H Aziz, Kui Cui, Mitali Das, Kathleen E Brown, Christopher L Ardell, Maria Febbraio, Elzbieta Pluskota, Juying Han, Huaizhu Wu, Christie M Ballantyne and 3 more

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. MMP12 induces fibrogenic macrophage differentiation to drive granuloma-associated cardiac fibrosis.American journal of respiratory and critical care medicine · 2026
    Article
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  8. bioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Moammir H AzizDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604.ORCID 0000-0003-1962-9063
Kui CuiDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604.
Mitali DasDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Kathleen E BrownDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Christopher L ArdellDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604.
Maria FebbraioDivision of Foundational Sciences, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
Elzbieta PluskotaDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.ORCID 0000-0003-2924-3842
Juying HanDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; and.ORCID 0000-0002-3416-2433
Huaizhu WuDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030.
Jonathan D SmithDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; and.ORCID 0000-0002-0415-386X
Martha K CathcartDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; and.
Valentin P YakubenkoDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604; yakubenko@etsu.edu.

Funding

Vascular Cell function and AtherosclerosisP01HL029582 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FOX, PAUL L · 1985 to 2019
$32.0M
Monocyte Activation and the Role of CD11c in obesity-linked metabolic syndromeR01HL098839 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WU, HUAIZHU · 2010 to 2019
$3.2M
The role of β2 integrins in macrophage retention and egress during inflammationR01DK102020 · NIDDK · EAST TENNESSEE STATE UNIVERSITY · PI YAKUBENKO, VALENTIN P · 2014 to 2017
$1.2M
Role of beta2 integrins in macrophage retention and egress during inflammationR56DK102020 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI YAKUBENKO, VALENTIN P · 2014 to 2014
$79k
NHLBI NIH HHS P01 HL029582NHLBI NIH HHS R01 HL098839NIDDK NIH HHS R01 DK102020NIDDK NIH HHS R56 DK102020
6 · The paper itself

Abstract

Macrophage accumulation is a critical step during development of chronic inflammation, initiating progression of many devastating diseases. Leukocyte-specific integrin α

Indexed as

AnimalsAortaApolipoproteins EAtherosclerosisBlood VesselsCD11 AntigensCD18 AntigensDiet, WesternHumansInflammationInflammation MediatorsIntegrin alpha ChainsMacrophagesMiceMice, KnockoutPeritonitisApolipoproteins ECD11 AntigensCD18 AntigensInflammation MediatorsIntegrin alpha Chainsintegrin alphaD, mouseITGAD protein, human

Identifiers

PMID28500072
PMCPMC5553324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.