Evidence map›Paper›PMID 28499988›Full record

ReviewBiochimica et biophysica acta. Molecular basis of disease2017

Melanocortin neurons: Multiple routes to regulation of metabolism.

Wen-Jie Shen, Ting Yao, Xingxing Kong, Kevin W Williams, Tiemin Liu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta. Molecular basis of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. The role of PYY in improving insulin resistance.Frontiers in endocrinology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Associations ofGenes · 2021
    Article
  12. The central melanocortin system and human obesity.Journal of molecular cell biology · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Wen-Jie ShenDepartment of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
Ting YaoDepartment of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi, China; Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200433, China.
Xingxing KongDivision of Pediatric Endocrinology, Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200433, China.
Kevin W WilliamsDivision of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA.
Tiemin LiuDepartment of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China; Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200433, China; Division of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA. Electronic address: tiemin.liu@utsouthwestern.edu.
First Affiliated Hospital of Chinese PLA General Hospital · CNFudan University · CNHarbin Medical University · CNThe University of Texas Southwestern Medical Center · USUniversity of California, Los Angeles · US

Funding

Central Mechanisms Regulating Acute Leptin and Insulin SignalingR01DK100699 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2014 to 2018
$1.8M
The Role of IRF4 in Exercise Induced ThermogenesisK99DK106550 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KONG, XINGXING · 2015 to 2016
$180k
NIDDK NIH HHS K99 DK106550NIDDK NIH HHS R01 DK100699
6 · The paper itself

Abstract

The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1,2]. A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3-6]. In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the energetic state [7-9]. Although the primary cause of obesity is unknown, there is significant effort to understand the role of the central melanocortin pathway in the brain as it has been shown that deficiency of proopiomelanocortin (POMC) [10,11] and melanocortin 4 receptors (MC4R) [12-15] in both rodents and humans results in severe hyperphagia and obesity [16-23]. In this review, we will summarize how the central melanocortin pathway helps regulate body mass and adiposity within a 'healthy' range through the 'nutrient sensing' network [24-28]. This article is part of a Special Issue entitled: Melanocortin Receptors - edited by Ya-Xiong Tao.

Indexed as

AnimalsEnergy MetabolismHumansHyperphagiaMelanocortinsMutationNeuronsObesityPro-OpiomelanocortinReceptor, Melanocortin, Type 4Signal TransductionMelanocortinsPro-OpiomelanocortinReceptor, Melanocortin, Type 4Agouti related peptide neuronsCentral melanocortin pathwayMelanocortin 4 receptorsMetabolismProopiomelanocortin neurons

Identifiers

PMID28499988
PMCPMC5600664
OpenAlexW2613695109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.