Evidence map›Paper›PMID 28499841›Full record

ArticleJournal of neuroscience methods2017

Effect of administration method, animal weight and age on the intranasal delivery of drugs to the brain.

Jishnu K S Krishnan, Peethambaran Arun, Bhadra Chembukave, Abhilash P Appu, Nivetha Vijayakumar, John R Moffett, Narayanan Puthillathu, Aryan M A Namboodiri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Nose-to-brain drug delivery: from bench to bedside.Translational neurodegeneration · 2025
    Review
  4. Article
  5. Article
  6. Research progress in brain-targeted nasal drug delivery.Frontiers in aging neuroscience · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?Journal of alternative and complementary medicine (New York, N.Y.) · 2018
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jishnu K S KrishnanDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
Peethambaran ArunDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
Bhadra ChembukaveDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
Abhilash P AppuDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
Nivetha VijayakumarDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
John R MoffettDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
Narayanan PuthillathuDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States.
Aryan M A NamboodiriDepartment of Anatomy, Physiology and Genetics, and Neurosciences Program, Uniformed Services University School of Medicine, USUHS, Bethesda, MD, United States. Electronic address: anamboodiri@usuhs.edu.
Uniformed Services University of the Health Sciences · US

Funding

Intranasal CNS delivery of drugs against organophosphorous threat agentsR21NS076448 · NINDS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI NAMBOODIRI, ARYAN MANGALAM · 2012 to 2013
$750k
NINDS NIH HHS R21 NS076448
6 · The paper itself

Abstract

backgroundThe intranasal route of administration has proven to be an effective method for bypassing the blood brain barrier and avoiding first pass hepatic metabolism when targeting drugs to the brain. Most small molecules gain rapid access to CNS parenchyma when administered intranasally. However, bioavailability is affected by various factors ranging from the molecular weight of the drug to the mode of intranasal delivery. COMPARISON WITH EXISTING

methodsWe examined the effects of animal posture, intranasal application method and animal weight and age on the delivery of radiolabeled pralidoxime (

resultsWe found that using upright vs. supine posture did not significantly affect

conclusionIn view of the emerging interest in the use of intranasal delivery of drugs to combat cognitive decline in old age, we tested effectiveness in very old rats and found the method to be as effective in the older rats.

Indexed as

Administration, IntranasalAfferent PathwaysAgingAnimalsAntidotesBody WeightBrainDrug Delivery SystemsMaleOlfactory BulbPralidoxime CompoundsRatsRats, Sprague-DawleyTrigeminal GanglionTritiumAntidotespralidoximePralidoxime CompoundsTritiumBioavailabilityBlood brain barrierGlymphatic systemIntranasal delivery devicePosture

Identifiers

PMID28499841
PMCPMC5517078
OpenAlexW2612567534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.