Evidence map›Paper›PMID 28499816›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2017

Tumor ablation using low-intensity ultrasound and sound excitable drug.

Ching-Hsuan Tung, Myung Shin Han, Young Kim, Jianjun Qi, Brian E O'Neill

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ching-Hsuan TungMolecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, United States; Department of Translational Imaging, Houston Methodist Research Institute, Houston, TX, United States. Electronic address: cht2018@med.cornell.edu.
Myung Shin HanMolecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, United States.
Young KimMolecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, United States.
Jianjun QiDepartment of Translational Imaging, Houston Methodist Research Institute, Houston, TX, United States.
Brian E O'NeillDepartment of Translational Imaging, Houston Methodist Research Institute, Houston, TX, United States.
Houston Methodist · USCornell University · USWeill Cornell Medicine · US

Funding

Sound excitable drugsR01GM094880 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TUNG, CHING-HSUAN · 2010 to 2014
$1.2M
NIGMS NIH HHS R01 GM094880
6 · The paper itself

Abstract

The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1MHz, 1W/cm

Indexed as

AnimalsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorCombined Modality TherapyFemaleHumansMiceMice, Inbred BALB CMice, NudeRose BengalUltrasonic TherapyXanthenesAntineoplastic AgentsRose BengalXanthenesPlasma membraneRuptureSonodynamic therapyTumor ablationUltrasound

Identifiers

PMID28499816
PMCPMC5515481
OpenAlexW2612837347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.