ArticleJournal of studies on alcohol and drugs2017
Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study.
Article in Journal of studies on alcohol and drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Trial
- Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood.Scientific reports · 2021Trial
- Drinking motives and alcohol sensitivity mediate multidimensional genetic influences on alcohol use behaviors.Alcohol, clinical & experimental research · 2025Article
- Addressing High Alcohol Consumption and Alcohol Use Disorders Among Adolescents and Young People in Sub-Saharan Africa: Pathways to Effective Action.Substance abuse and rehabilitation · 2025Review
- Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.Development and psychopathology · 2024Article
- Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features.Behavioral sciences (Basel, Switzerland) · 2023Article
- Risk factors for early use of e-cigarettes and alcohol: Dimensions and profiles of temperament.Development and psychopathology · 2023Article
- Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects.Molecular psychiatry · 2022Observational
- Relationship between sensation seeking, alcohol problems and bulimic symptoms: a community-based, longitudinal study.Eating and weight disorders : EWD · 2022Article
- Agreement between DSM-5 and DSM-IV measures of substance use disorders in a sample of adult substance users.Drug and alcohol dependence · 2021Article
- The associations between polygenic risk, sensation seeking, social support, and alcohol use in adulthood.Journal of abnormal psychology · 2021Article
- Predicting alcohol use disorder remission: a longitudinal multimodal multi-featured machine learning approach.Translational psychiatry · 2021Article
- Differential predictors for alcohol use in adolescents as a function of familial risk.Translational psychiatry · 2021Article
- The Differential Heritability of Social Adjustment by Sex.International journal of environmental research and public health · 2021Article
- Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.Journal of youth and adolescence · 2020Article
- Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood.Development and psychopathology · 2020Article
- Assessing phenotypic and polygenic models of ADHD to identify mechanisms of risk for longitudinal trajectories of externalizing behaviors.Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- Sex Differences in the Effect of Nucleus Accumbens Volume on Adolescent Drinking: The Mediating Role of Sensation Seeking in the NCANDA Sample.Journal of studies on alcohol and drugs · 2019Article
- FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Review
- Unpacking Genetic Risk Pathways for College Student Alcohol Consumption: The Mediating Role of Impulsivity.Alcoholism, clinical and experimental research · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveAlcohol use problems are common during adolescence and can predict serious negative outcomes in adulthood, including substance dependence and psychopathology. The current study examines the notion that alcohol use problems are driven by polygenic influences and that genetic influences may indirectly affect alcohol use problems through multiple pathways of risk, including variations in personality.
methodWe used a genome-wide approach to examine associations between genetic risk for alcohol use problems, personality dimensions, and adolescent alcohol use problems in two separate longitudinal population-based samples, the Finnish Twin Cohort (FinnTwin12) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants were 1,035 young adults from FinnTwin12 and 3,160 adolescents from ALSPAC. Polygenic risk scores (PRS) were calculated for ALSPAC using genome-wide association results (on alcohol dependence symptoms as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) from FinnTwin12. A parallel multiple mediator model was tested to examine whether the association between PRS and alcohol use problems assessed at age 16 could be explained by variations in personality dimensions assessed at age 13, including sensation seeking and negative emotionality.
resultsPRS were marginally predictive of age 16 alcohol use problems; this association was partially mediated by sensation seeking. Polygenic variation underlying risk for alcohol use problems may directly influence the effects of sensation seeking, which in turn influence the development of alcohol use problems in later adolescence.
conclusionsThese findings contribute to the increasing evidence regarding the salience of sensation seeking during early adolescence as a potential constituent in the risk pathway underlying the development of alcohol use problems.
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