ArticleThe Journal of infectious diseases2017
Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- A controlled human malaria infection model enabling evaluation of transmission-blocking interventions.The Journal of clinical investigation · 2018Trial
- Trial
- Elevated Plasmodium falciparum sexual conversion in HbAC and HbAS red blood cells in naturally infected malaria patients.PLoS pathogens · 2026Article
- Prevalence ofPathogens (Basel, Switzerland) · 2026Article
- An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs.Nature communications · 2025Article
- Plasmodium falciparum gametocyte production correlates with genetic markers of parasite replication but is not influenced by experimental exposure to mosquito biting.EBioMedicine · 2024Article
- Gametocyte prevalence and risk factors of P. falciparum malaria patients admitted at the Hospital for Tropical Diseases, Thailand: a 20-year retrospective study.Malaria journal · 2023Article
- Controlled Human Infection Models To Accelerate Vaccine Development.Clinical microbiology reviews · 2022Review
- The acquisition of humoral immune responses targetingFrontiers in immunology · 2022Article
- Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages.Scientific reports · 2021Article
- Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.Nature communications · 2021Article
- Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season.BMC infectious diseases · 2021Article
- Assays for quantification of male and female gametocytes in human blood by qRT-PCR in the absence of pure sex-specific gametocyte standards.Malaria journal · 2020Article
- Human Plasmodium vivax mosquito experimental transmission.The Journal of clinical investigation · 2020Article
- Plasmodium asexual growth and sexual development in the haematopoietic niche of the host.Nature reviews. Microbiology · 2020Review
- HIV-1 Infection Is Associated With Increased Prevalence and Abundance ofFrontiers in cellular and infection microbiology · 2020Article
- Impact of an Irrigation Dam on the Transmission and Diversity ofJournal of tropical medicine · 2020Article
- Reporter lines based on the gexp02 promoter enable early quantification of sexual conversion rates in the malaria parasite Plasmodium falciparum.Scientific reports · 2019Article
- Gametocyte Sex Ratio: The Key to Understanding Plasmodium falciparum Transmission?Trends in parasitology · 2019Review
- Complex Determination of the Gametocyte Conversion Rate.Trends in parasitology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent focus on the elimination of malaria has led to an increased interest in the role of sexual stages in its transmission. We introduce Plasmodium falciparum gametocyte exported protein-5 (PfGEXP5) transcript analysis as an important tool for evaluating the earliest (ring) stage sexual gametocytes in the blood of infected individuals. We show that gametocyte rings are detected in the peripheral blood immediately following establishment of asexual infections-without the need for triggers such as high-density asexual parasitemia or drug treatment. Committed gametocytes are refractory to the commonly used drug piperaquine, and mature gametocytes reappear in the bloodstream 10 days after the initial appearance of gametocyte rings. A further wave of commitment is observed following recrudescent asexual parasitemia, and these gametocytes are again refractory to piperaquine treatment. This work has implications for monitoring gametocyte and transmission dynamics and responses to drug treatment.
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Registered trials
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