Evidence map›Paper›PMID 28498973›Full record

ArticleJournal of neuropathology and experimental neurology2017

Chordoma Occurs in Young Children With Tuberous Sclerosis.

Nathan A Dahl, Timothy Luebbert, Michele Loi, Ilana Neuberger, Michael H Handler, Bette Kay Kleinschmidt-DeMasters, Jean M Mulcahy Levy

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. A 13-year patient journey of infant giant clival chordoma: case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  3. Metastatic skull base chordoma: A systematic review.Laryngoscope investigative otolaryngology · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nathan A DahlFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Timothy LuebbertFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Michele LoiFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Ilana NeubergerFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Michael H HandlerFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Bette Kay Kleinschmidt-DeMastersFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Jean M Mulcahy LevyFrom the Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (NAD, TL, ML, JMM-L); Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado (NAD, JMM-L); Department of Neurology (TL, BKK-D); Department of Radiology (IN); Department of Neurosurgery (MHH, BKK-D); and Department of Pathology, University of Colorado Denver, Aurora, Colorado (BKK-D).
Children's Hospital Colorado · USMorgan Adams Foundation · USUniversity of Colorado Denver · US

Funding

The Interaction of Autophagy and BRAF Mutations in Brain TumorsK08CA193982 · NCI · UNIVERSITY OF COLORADO DENVER · PI MULCAHY LEVY, JEAN MARIE · 2015 to 2019
$822k
NCI NIH HHS K08 CA193982
6 · The paper itself

Abstract

Chordomas are rare bony neoplasms usually unassociated with a familial tumor predisposition syndrome. The peak incidence of this midline axial skeletal tumor is in adulthood but when very young children are affected, consideration should be given to occurrence within the tuberous sclerosis (TS) complex, especially when presenting in neonates <3 months of age. To call attention to this association, we present a brachyury-immunopositive chordoma occurring in the skull base of a 2-month-old male infant who was later realized to have metastases to the subcutaneous tissues and lungs, as well as rhabdomyoma of the heart and renal cysts/angiomyolipomas, that is, characteristic features of the TS complex. We review the limited literature on this topic.

Indexed as

AngiomyolipomaChordomaHeart NeoplasmsHumansInfantKidney NeoplasmsLung NeoplasmsMagnetic Resonance ImagingMaleNeoplasm MetastasisRhabdomyomaSkin NeoplasmsSkull Base NeoplasmsTuberous SclerosisTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsAngiomyolipomaBrachyuryChordomaNeonatalPediatric neoplasmRhabdomyomaTuberous sclerosis

Identifiers

PMID28498973
PMCPMC6075544
OpenAlexW2613683489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.