Evidence map›Paper›PMID 28498934›Full record

ReviewNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2018

Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.

Li-Shiun Chen, Laurie Zawertailo, Thomas M Piasecki, Jaakko Kaprio, Marilyn Foreman, Hannah R Elliott, Sean P David, Andrew W Bergen, James W Baurley, Rachel F Tyndale and 4 more

Abstract readReview
In one paragraph

Review in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Epigenetic biomarkers for smoking cessation.Addiction neuroscience · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Biomarkers for Tobacco Exposures, Toxicology, Regulation, and Cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018
    Article
  15. The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Li-Shiun ChenSiteman Cancer Center, Institute of Public Health, and Department of Psychiatry, Washington University School of Medicine, St. Louis, MI.
Laurie ZawertailoNicotine Dependence Service, Centre for Addiction and Mental Health, and Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Thomas M PiaseckiDepartment of Psychological Sciences, University of Missouri, Columbia, MI.
Jaakko KaprioInstitute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Marilyn ForemanPulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, GA.
Hannah R ElliottMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Sean P DavidDepartment of Medicine, Stanford University, Stanford, CA.
Andrew W BergenBioRealm, Culver City, CA.
James W BaurleyBioRealm, Culver City, CA.
Rachel F TyndaleCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, and Departments of Pharmacology & Toxicology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Timothy B BakerTobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Laura J BierutSiteman Cancer Center, Institute of Public Health, and Department of Psychiatry, Washington University School of Medicine, St. Louis, MI.
Nancy L SacconeDepartment of Genetics, Washington University School of Medicine, St. Louis, MI.
Genetics and Treatment Workgroup of the Society for Research on Nicotine and Tobacco (SRNT)

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
University of Toronto Coordinating Genetics Core & Clinical Trial SiteU01DA020830 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI LERMAN, CARYN, TYNDALE, RACHEL FYNVOLA · 2005 to 2014
$22.4M
STEERING COMMITTEEU54MD008149 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI OFILI, ELIZABETH O. · 2012 to 2018
$21.1M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Enhancing the Effectiveness of Varenicline Based Smoking Cessation TreatmentR01HL109031 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TIMOTHY B, STEIN, JAMES H · 2011 to 2020
$17.5M
Trial of strategies to communicate genetic information to different ethnic and racial subpopulationsU54MD010724 · NIMHD · STANFORD UNIVERSITY · PI MALDONADO, YVONNE A. · 2016 to 2021
$16.3M
Extended Treatment for Smoking CessationR01DA017441 · NIDA · STANFORD UNIVERSITY · PI DAVID, SEAN P. · 2003 to 2013
$5.2M
Genetically Informed Smoking Cessation TrialR01DA038076 · NIDA · WASHINGTON UNIVERSITY · PI CHEN, LI-SHIUN · 2014 to 2018
$3.3M
Nicotine Dependence to Smoking Cessation: Sequencing Common and Rare VariantsR01DA036583 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2014 to 2017
$3.0M
HUMAN GENETIC VARIATION IN SMOKING AND ADDICTION RISKR01DA026911 · NIDA · WASHINGTON UNIVERSITY · PI SACCONE, NANCY L · 2009 to 2013
$2.1M
Smokescreen Translational (TL) Analysis PlatformR44AA027675 · NIAAA · BIOREALM · PI BAURLEY, JAMES WILLIAM, BERGEN, ANDREW W · 2018 to 2020
$1.7M
Medical Research Council MC_UU_12013/2NCI NIH HHS K05 CA139871NCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL109031NIAAA NIH HHS R44 AA027675NIDA NIH HHS K08 DA030398NIDA NIH HHS R01 DA017441NIDA NIH HHS R01 DA026911NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA038076NIDA NIH HHS R21 DA033813NIDA NIH HHS R43 DA041211NIDA NIH HHS RC2 DA028793NIDA NIH HHS U01 DA020830NIDCD NIH HHS F32 DC000190NIMHD NIH HHS U54 MD008149NIMHD NIH HHS U54 MD010724
6 · The paper itself

Abstract

Implications: This article outlines a framework for the consistent integration of biological data/samples into smoking cessation pharmacotherapy trials, aligned with the objectives of the recently unveiled Precision Medicine Initiative. Our goal is to encourage and provide support for treatment researchers to consider biosample collection and genotyping their existing samples as well as integrating genetic analyses into their study design in order to realize precision medicine in treatment of nicotine dependence.

Indexed as

Clinical Trials as TopicGenomicsHumansPrecision MedicineSmokingSmoking CessationTobacco Use Cessation DevicesTobacco Use Disorder

Identifiers

PMID28498934
PMCPMC5896450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.