ArticlePloS one2017
Associations of androgens with depressive symptoms and cognitive status in the general population.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis.JAMA psychiatry · 2019Pooled it
- Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study.Climacteric : the journal of the International Menopause Society · 2025Article
- Causal effects of genetically predicted testosterone on Alzheimer's disease: a two-sample mendelian randomization study.Acta neurologica Belgica · 2024Article
- Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis.Frontiers in aging neuroscience · 2024Article
- Association between serum globulin and cognitive impairment in older American adults.Frontiers in public health · 2023Article
- Relationships between Plasma Concentrations of Testosterone and Dihydrotestosterone and Geriatric Depression Scale Scores in Men and Women Aged 60-65 Years-A Multivariate Approach with the Use of Quade's Test.International journal of environmental research and public health · 2022Article
- Combined repetitive transcranial magnetic stimulation and medication treatment for depression is associated with serum amyloid a level: Evidence from naturalistic clinical practice.Frontiers in neuroscience · 2022Article
- Testosterone Replacement Therapy in the Treatment of Depression.Health psychology research · 2022Article
- The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health.Sexual medicine · 2021Article
- Plasma androgens and the presence and course of depression in a large cohort of women.Translational psychiatry · 2021Article
- Low Serum Testosterone Concentrations Are Associated With Poor Cognitive Performance in Older Men but Not Women.Frontiers in aging neuroscience · 2021Article
- Androgen Therapy in Neurodegenerative Diseases.Journal of the Endocrine Society · 2020Review
- Bioavailable testosterone is associated with symptoms of depression in adult men.The Journal of international medical research · 2020Article
- Predicting rehospitalization within 2 years of initial patient admission for a major depressive episode: a multimodal machine learning approach.Translational psychiatry · 2019Article
- Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.Psychoneuroendocrinology · 2019Article
- Testosterone is related to GABA+ levels in the posterior-cingulate in unmedicated depressed women during reproductive life.Journal of affective disorders · 2019Article
- Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines.Advances in pharmacological sciences · 2019Review
- Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain.European journal of endocrinology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAssociations between androgens and depressive symptoms were mostly reported from cross-sectional and patient-based studies. STUDY DESIGN/
main outcome measuresLongitudinal data from 4,110 participants of the Study of Health in Pomerania were used to assess sex-specific associations of baseline total and free testosterone, androstenedione and sex hormone-binding globulin with incident depressive symptoms and cognitive status at 5- and 10-year follow-up.
resultsDespite sex-specific differences in depressive symptoms prevalence at baseline (women: 17.4%, men: 8.1%), cross-sectional analyses showed no associations between sex hormones and depressive symptoms. In age-adjusted longitudinal analyses, total testosterone was associated with incident depressive symptoms (relative risk at 5-year follow-up: 0.73, 95% confidence interval: 0.58-0.92). Similarly, age-adjusted analyses showed a positive association between sex hormone-binding globulin and cognitive status in men (β-coefficient per standard deviation: 0.44, 95% confidence interval: 0.13-0.74). In women, age-adjusted associations of androstenedione with baseline depressive symptoms (relative risk: 0.88, 95% confidence interval: 0.77-0.99) were found. None of the observed associations remained after multivariable adjustment.
conclusionsThe present population-based, longitudinal study revealed inverse associations between sex hormones and depressive symptoms. However, the null finding after multivariable adjustment suggests, that the observed associations were not independent of relevant confounders including body mass index, smoking and physical inactivity. Furthermore, the low number of incident endpoints in our non-clinical population-based sample limited the statistical power and reduced the chance to detect a statistically significant effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.