ArticlePloS one2017
A Drosophila model for developmental nicotine exposure.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Symbiont-mediated detoxification: Wolbachia alters the transcriptomic and metabolic landscape of Drosophila under nicotine stress.BMC genomics · 2026Article
- Fluctuating Asymmetry Spotted Wing Drosophila (Diptera: Drosophilidae) Exposed to Sublethal Doses of Acetamiprid and Nicotine.Insects · 2024Article
- Article
- Article
- Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways.Scientific reports · 2021Article
- Smoking flies: testing the effect of tobacco cigarettes on heart function ofBiology open · 2021Article
- The mirtron miR-1010 functions in concert with its host gene SKIP to balance elevation of nAcRβ2.Scientific reports · 2020Article
- The Neurotransmitters Involved inFrontiers in behavioral neuroscience · 2020Review
- HCN2 Channel-Induced Rescue of Brain TeratogenesisFrontiers in cellular neuroscience · 2020Article
- Using invertebrate model organisms for neuroscience research and training: an opportunity for Africa.Metabolic brain disease · 2018Article
- Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.BMC developmental biology · 2018Article
- HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns.Nature communications · 2018Article
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genetic and molecular mechanisms for drugs of abuse. Here I show that Drosophila can be a model to elucidate the mechanisms for nicotine's effects on a developing organism. Drosophila reared on nicotine food display developmental and behavioral effects similar to those in mammals including decreased survival and weight, increased developmental time, and decreased sensitivity to acute nicotine and ethanol. The Drosophila nicotinic acetylcholine receptor subunit alpha 7 (Dα7) mediates some of these effects. A novel role for Dα7 on ethanol sedation in Drosophila is also shown. Future research taking advantage of the genetic and molecular tools for Drosophila will allow additional discovery of the mechanisms behind the effects of nicotine during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.