ArticlePLoS genetics2017
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
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68citing papers in PubMed, 6 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
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Who cites it
68 citing papers in PubMed, 6 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study.Nature communications · 2023Pooled it
- Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits.International journal of molecular sciences · 2023Pooled it
- Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.Genetic epidemiology · 2022Pooled it
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Pooled it
- Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Nature communications · 2026Article
- Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.Atherosclerosis · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Genetics of Hypertension: From Monogenic Analysis to GETomics.Journal of cardiovascular development and disease · 2024Review
- Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets.Nature communications · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.Nature communications · 2023Article
- meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans.Nature communications · 2023Article
- Overcoming the underdiagnosis of obstructive sleep apnea to empower genetic association analyses.Sleep · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Article
- Article
- Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications.Kidney international · 2022Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
79 authors at 20 institutions in 5 countries.
Jingjing LiangDepartment of Epidemiology & Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States of America.
Thu H LeDepartment of Medicine, Division of Nephrology, University of Virginia, Charlottesville, Virginia, United States of America.
Digna R Velez EdwardsDepartment of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America.
Kyle J GaultonDepartment of Pediatrics, University of California San Diego, La Jolla, California, United States of America.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.ORCID http://orcid.org/0000-0002-3575-5468
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America.
Richard A JensenCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.ORCID http://orcid.org/0000-0001-7117-1075
Karen SchwanderDivision of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America.
Salman M TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.ORCID http://orcid.org/0000-0002-7919-8528
Tamar SoferDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.ORCID http://orcid.org/0000-0001-8520-8860
Wonji KimInterdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-1249-797X
James KayimaDivision of Adult Cardiology, Uganda Heart Institute, Makerere University College of Health Sciences, Kampala, Uganda.ORCID http://orcid.org/0000-0002-4676-7819
Colin A McKenzieTropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies, Mona, Jamaica.
Ervin FoxDepartment of Preventive Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Michael A NallsData Tecnica International, Glen Echo, MD, United States of America and Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, Maryland, United States of America.
J Hunter YoungDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Yan V SunDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.ORCID http://orcid.org/0000-0002-2838-1824
Jacqueline M LaneCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Sylvia CechovaDepartment of Medicine, Division of Nephrology, University of Virginia, Charlottesville, Virginia, United States of America.ORCID http://orcid.org/0000-0001-7631-7707
Jie ZhouCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Hua TangDepartment of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.
Myriam FornageInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, United States of America.
Solomon K MusaniDepartment of Preventive Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Heming WangDepartment of Epidemiology & Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States of America.
Juyoung LeeDivision of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Cheongju, Republic of Korea.ORCID http://orcid.org/0000-0002-1729-2383
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.ORCID http://orcid.org/0000-0002-3105-3231
Albert W DreisbachDepartment of Preventive Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.ORCID http://orcid.org/0000-0002-9658-0198
Terrence ForresterTropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies, Mona, Jamaica.
Pei-Lun ChuDepartment of Internal Medicine, Graduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Anne CappolaDivision of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States of America.ORCID http://orcid.org/0000-0002-0883-9754
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Alanna C MorrisonHuman Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, United States of America.
Lisa W MartinThe George Washington University School of Medicine and Health Sciences, Washington DC. United States of America.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Qin HuiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Rebecca D JacksonDepartment of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America.
Erin B WareDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.ORCID http://orcid.org/0000-0003-4731-8158
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan Ann Arbor, Michigan, United States of America.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Michael BrayDepartment of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Joshua C DennyDepartment of Biomedical Informatics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Thomas H MosleyDepartment of Preventive Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Walter PalmasDepartment of Medicine, Columbia University, New York City, New York, United States of America.
Xiuqing GuoMedical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.
George J PapanicolaouDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.ORCID http://orcid.org/0000-0003-1036-4329
Alan D PenmanDepartment of Preventive Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.ORCID http://orcid.org/0000-0002-6745-4635
Joseph F PolakTufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.ORCID http://orcid.org/0000-0001-5779-4495
Ken D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, United States of America.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America.
Kiang LiuDepartment of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, United States of America.
Neil RischInstitute for Human Genetics, University of California, San Francisco, California, United States of America.
Steven C HuntCardiovascular Genetics, University of Utah, Salt Lake City, Utah, United States of America.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.ORCID http://orcid.org/0000-0003-2572-4040
Diane M BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Jianwen CaiDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan Ann Arbor, Michigan, United States of America.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Donna K ArnettUniversity of Kentucky, College of Public Health, Lexington, KY.
Sungho WonInterdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Institute of Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilit University Medical Center, Nashville, Tennessee, United States of America.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Richard S CooperDepartment of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America.
D C RaoDivision of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.ORCID http://orcid.org/0000-0001-7191-1723
Charles RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD, and the Framingham Heart Study, Framingham, Massachusetts, United States of America.
Aravinda ChakravartiMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Xiaofeng ZhuDepartment of Epidemiology & Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States of America.
Nora FranceschiniEpidemiology, Gilling School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America.ORCID http://orcid.org/0000-0001-9755-2175
National Institutes of Health · USUniversity of Michigan · USUniversity of Mississippi Medical Center · USUniversity of Washington · USJohns Hopkins University · USVanderbilt University Medical Center · USCase Western Reserve University · USThe University of Texas Health Science Center at Houston · USEmory University · USFred Hutch Cancer Center · USLoyola University Chicago · USSeoul National University · KRThe Lundquist Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of the West Indies · JMUniversity of Virginia · USWashington University in St. Louis · USBrigham and Women's Hospital · USBroad Institute · USCedars-Sinai Medical Center · US
Funding
Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)ZIAAG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$70.9MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MFramingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MHYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MGenomics of blood pressure-induced target organ damageR01HL128782 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2015 to 2018
$7.8MBIOMETRIC-GENETIC ANALYSIS OF CARDIOVASCULAR DISEASET32HL007567 · NHLBI · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ZHU, XIAOFENG · 1985 to 2021
$6.0MStatistical methods for analyzing high-throughput genotype dataR01HG003054 · NHGRI · LOYOLA UNIVERSITY CHICAGO · PI ZHU, XIAOFENG · 2005 to 2017
$3.6MDiverse ancestry biobank to map biomedical traits and elucidate health disparitieU01HG007417 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2013 to 2017
$3.5MNCATS NIH HHS UL1 TR000124NHGRI NIH HHS R01 HG003054NHGRI NIH HHS U01 HG007417NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128782NHLBI NIH HHS R21 HL121429NHLBI NIH HHS R21 HL123677NHLBI NIH HHS T32 HL007567NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK094907NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R01 GM073059NIH HHS S10 OD018522NIH HHS S10 OD020069
Abstract
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.25×10-8) for either systolic and diastolic blood pressure, hypertension, or for combined traits. Single-trait analyses identified two loci (TARID/TCF21 and LLPH/TMBIM4) and multiple-trait analyses identified one novel locus (FRMD3) for blood pressure. At these three loci, as well as at GRP20/CDH17, associated variants had alleles common only in African-ancestry populations. Functional annotation showed enrichment for genes expressed in immune and kidney cells, as well as in heart and vascular cells/tissues. Experiments driven by these findings and using angiotensin-II induced hypertension in mice showed altered kidney mRNA expression of six genes, suggesting their potential role in hypertension. Our study provides new evidence for genes related to hypertension susceptibility, and the need to study African-ancestry populations in order to identify biologic factors contributing to hypertension.
Indexed as
Genetic LociMultifactorial InheritanceAnimalsBasic Helix-Loop-Helix ProteinsBlack or African AmericanBlood PressureCadherinsCase-Control StudiesFemaleGenome-Wide Association StudyHumansHypertensionMaleMembrane ProteinsMicePolymorphism, Single NucleotideBasic Helix-Loop-Helix ProteinsCadherinsCDH17 protein, humanMembrane ProteinsTCF21 protein, humanTMBIM4 protein, human
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