ArticleVirulence2017
The distinct function of Tep2 and Tep6 in the immune defense of Drosophila melanogaster against the pathogen Photorhabdus.
Article in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 38 citations in OpenAlex.
- Thioester-containing protein TEP15 promotes malaria parasite development in mosquitoes through negative regulation of melanization.Parasites & vectors · 2025Article
- Delayed host mortality and immune response upon infection withInfection and immunity · 2023Article
- Interactions between innate immunity and insulin signaling affect resistance to infection in insects.Frontiers in immunology · 2023Review
- A balance between vector survival and virus transmission is achieved through JAK/STAT signaling inhibition by a plant virus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular characterization of thioester-containing proteins inFrontiers in immunology · 2022Article
- Haemocyte-mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites.Immunology · 2021Review
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- Activin and BMP Signaling Activity Affects Different Aspects of Host Anti-Nematode Immunity inFrontiers in immunology · 2021Article
- Thioester-containing Proteins in theInsects · 2020Review
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- TGF-β Signaling Interferes With theFrontiers in physiology · 2019Article
- Social environment affects the transcriptomic response to bacteria in ant queens.Ecology and evolution · 2018Article
- Thioester-containing proteins in the tsetse fly (Glossina) and their response to trypanosome infection.Insect molecular biology · 2018Article
- Quorum-sensing regulator RhlR but not its autoinducer RhlI enablesEMBO reports · 2018Article
- Thioester-Containing Proteins 2 and 4 Affect the Metabolic Activity and Inflammation Response in Drosophila.Infection and immunity · 2018Article
- Rapid seasonal evolution in innate immunity of wildProceedings. Biological sciences · 2018Article
- BgTEP: An Antiprotease Involved in Innate Immune Sensing inFrontiers in immunology · 2018Article
- Article
- Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response.Frontiers in immunology · 2017Review
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3 authors at 1 institution in 1 country.
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Abstract
Previous and recent investigations on the innate immune response of Drosophila have identified certain mechanisms that promote pathogen elimination. However, the function of Thioester-containing proteins (TEPs) in the fly still remains elusive. Recently we have shown the contribution of TEP4 in the antibacterial immune defense of Drosophila against non-pathogenic E. coli, and the pathogens Photorhabdus luminescens and P. asymbiotica. Here we studied the function of Tep genes in both humoral and cellular immunity upon E. coli and Photorhabdus infection. We found that while Tep2 is induced after Photorhabdus and E. coli infection; Tep6 is induced by P. asymbiotica only. Moreover, functional ablation of hemocytes results in significantly low transcript levels of Tep2 and Tep6 in response to Photorhabdus. We show that Tep2 and Tep6 loss-of-function mutants have prolonged survival against P. asymbiotica, Tep6 mutants survive better the infection of P. luminescens, and both tep mutants are resistant to E. coli and Photorhabdus. We also find a distinct pattern of immune signaling pathway induction in E. coli or Photorhabdus infected Tep2 and Tep6 mutants. We further show that Tep2 and Tep6 participate in the activation of hemocytes in Drosophila responding to Photorhabdus. Finally, inactivation of Tep2 or Tep6 affects phagocytosis and melanization in flies infected with Photorhabdus. Our results indicate that distinct Tep genes might be involved in different yet crucial functions in the Drosophila antibacterial immune response.
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