ReviewInternational journal of molecular sciences2017
Chronic Kidney Disease and Exposure to Nephrotoxic Metals.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05031013 (Trace Elements Concentration in Dialysis), which is not on this map. Cited by 155 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trace Elements Concentration in Dialysis
Who cites it
155 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure.Environmental science and pollution research international · 2022Pooled it
- Article
- Bioaccumulation and Human Health Risk Assessment of Potentially Toxic Elements in Commercial Fish Species (International journal of environmental research and public health · 2026Article
- Comprehensive sub-chronic toxicological profiling of illegal artisanal small-scale mining-polluted river bodies in four regions of Ghana.Toxicology reports · 2026Article
- Co-exposure to environmental cadmium and arsenic leads to kidney damage even at lower concentrations.Journal of exposure science & environmental epidemiology · 2026Article
- Review
- JUNB transcriptional regulation of KRT20 via ITGB1 activates PI3K/AKT signaling pathway against fibrosis-induced by renal injury.Biology direct · 2026Article
- Toenail metal concentrations and kidney health among young people at risk of chronic kidney disease of uncertain etiology.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Associations Between Toxic Metal Exposure and Childhood Nephrotic Syndrome.Kidney international reports · 2026Article
- Associations of plasma concentrations of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease: a population-based study.Clinical kidney journal · 2026Article
- Eucalyptol alleviates lead-induced nephrotoxicity in rats by suppressing oxidative stress, inflammation, and apoptosis, and enhancing the Nrf2/HO-1 signaling pathway.Biological trace element research · 2026Article
- Spatial coupling and individual-level evidence: linking rice cadmium exposure to liver cancer in a high-risk area of China.Environmental geochemistry and health · 2026Article
- Article
- Unveiling the potential of extracellular and outer membrane vesicles in fish aquaculture: a comprehensive review.Frontiers in immunology · 2026Review
- Metal carcinogens and cancer: integrating genetic and epigenetic perspectives.Frontiers in oncology · 2026Review
- Associations of children's urinary metals with blood RNA NEnvironmental research · 2025Article
- Association of metal and metalloid exposure with cardiovascular-kidney-metabolic syndrome: mediation by inflammation, oxidative stress, and aging.BMC public health · 2025Article
- Association of Tumor Necrosis Factor Alpha Gene Polymorphism (TNF-α 308 G/A) with Enhanced Severity of Metal-Induced Chronic Kidney Disease via Upregulation of Transmembrane Protein Expression.Biological trace element research · 2025Article
- Longitudinal Nephrotoxic Metal Exposure in a Cohort of Farm Workers in Sonora, Mexico.Journal of occupational and environmental medicine · 2025Article
- The AST/ALT ratio as a mediator of heavy metal exposure and diabetic kidney disease (DKD) risk: A NHANES study.Scientific reports · 2025Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.