Evidence map›Paper›PMID 28498311›Full record

ReviewInternational journal of molecular sciences2017

Differential Immune Responses to New World and Old World Mammalian Arenaviruses.

Hinh Ly

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Strategies of rational and structure-driven vaccine design for Arenaviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024
    Review
  4. Review
  5. Structural and molecular biology of Sabiá virus.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Synanthropic rodents as virus reservoirs and transmitters.Revista da Sociedade Brasileira de Medicina Tropical · 2020
    Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hinh LyDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, 1988 Fitch Ave., Ste 295, Saint Paul, MN 55108, USA. hly@umn.edu.
University of Minnesota · US

Funding

Mechanism of Lassa fever virus Z protein in immune suppression and viral virulenceR01AI131586 · NIAID · UNIVERSITY OF MINNESOTA · PI LIANG, YUYING, LY, HINH · 2017 to 2021
$3.8M
Novel Mechanism of Immune Evasion by Arenaviral NucleoproteinsR01AI093580 · NIAID · UNIVERSITY OF MINNESOTA · PI LY, HINH · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI093580NIAID NIH HHS R01 AI131586
6 · The paper itself

Abstract

Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed immune function in progressive disease stage, whereas patients infected with Junín virus (JUNV) develop overt pro-inflammatory cytokine production. These viruses have also evolved different molecular strategies to evade host immune recognition and activation. This paper summarizes current progress in understanding the differential immune responses to pathogenic arenaviruses and how the information can be exploited toward the development of vaccines against them.

Indexed as

AnimalsHemorrhagic Fever, AmericanHumansImmune EvasionJunin virusLassa FeverLassa virusViral VaccinesViral Vaccinesarenaviruseshemorrhagic feverimmune evasionJuninLassavaccine

Identifiers

PMID28498311
PMCPMC5454952
OpenAlexW2612384738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.