Evidence map›Paper›PMID 28498106›Full record

ArticleeLife2017

Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria.

Michael A Ferrin, Arvind R Subramaniam

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Collided ribosomes are rescued by the endonuclease Rae1 andbioRxiv : the preprint server for biology · 2026
    Article
  3. eIF5A and polyamines restrict mRNA levels in response to ribosome stalls.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael A FerrinBasic Sciences Division and Computational Biology Program of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0002-9899-1169
Arvind R SubramaniamBasic Sciences Division and Computational Biology Program of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-6145-4303
National Institutes of Health · US

Funding

Regulation of Protein Synthesis by Synonymous Codon UsageR35GM119835 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SUBRAMANIAM, ARVIND RASI · 2016 to 2025
$4.1M
Role of Synonymous Codons as Gene Regulators in Bacteria and Cancer CellsR00GM107113 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SUBRAMANIAM, ARVIND RASI · 2015 to 2016
$498k
NIGMS NIH HHS R00 GM107113NIGMS NIH HHS R35 GM119835
6 · The paper itself

Abstract

Ribosome stalling on mRNAs can decrease protein expression. To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium

Indexed as

Protein BiosynthesisComputer SimulationEscherichia coliKineticsRibosomesamino acid starvationcomputational biologyE. colikinetic modelingpremature terminationquality controlribosome collisionsribosome stallingsystems biology

Identifiers

PMID28498106
PMCPMC5446239
OpenAlexW2612290321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.