ReviewThe world journal of men's health2017
Role of Antioxidants in Assisted Reproductive Techniques.
Review in The world journal of men's health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05919186 (Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations
Who cites it
47 citing papers in PubMed, 101 citations in OpenAlex.
- Enhancing the Oocyte Ultrastructure and Antioxidant Defence System of In Vitro Matured Buffalo Oocytes via Resveratrol Supplementation.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Protective effects of Demethylfuropinnarin on porcine pre-implantation embryos under Tunicamycin-induced oxidative stress and endoplasmic reticulum stress during in vitro culture.Scientific reports · 2026Article
- Mechanisms of seminal plasma synthesis and actions on sperm function for advancing reproductive technologies.The Journal of reproduction and development · 2026Review
- The role of oxidative stress in sleep deprivation-induced reproductive dysfunction: A rationale for anti-oxidant intervention.Iranian journal of basic medical sciences · 2026Review
- Dietary Supplementation With CoQ10 and Sel-Plex Mitigates the Effects of Elevated Water Temperature on Performance, Digestive Physiology, Immune Competence, and Antioxidant Balance in Rainbow Trout.Aquaculture nutrition · 2026Article
- Parental dietary patterns and assisted reproductive technology outcomes including embryo morphokinetics: rotterdam periconception cohort.Journal of assisted reproduction and genetics · 2025Article
- Reductive stress and the role of antioxidants in male infertility: a narrative review.Archives of gynecology and obstetrics · 2025Review
- Dietary melatonin supplementation mitigates the negative effects of artificial light at night in the Pacific field cricket,Proceedings. Biological sciences · 2025Article
- Edaravone Mitigates Postovulatory Aging by Preserving Oocyte and Embryo Quality in Mice.Antioxidants (Basel, Switzerland) · 2025Article
- The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications.Antioxidants (Basel, Switzerland) · 2025Review
- A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species.Current issues in molecular biology · 2025Review
- Andrology laboratory techniques for micro-TESE/IVF/ICSI: a narrative review.Asian journal of andrology · 2025Review
- Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health.Cells · 2025Review
- Micronutrient Antioxidants for Men (MenevitAntioxidants (Basel, Switzerland) · 2024Article
- α-Pinene Improves Follicle Morphology and Increases the Expression of mRNA for Nuclear Factor Erythroid 2-Related Factor 2 and Peroxiredoxin 6 in Bovine Ovarian Tissues Cultured In Vitro.Animals : an open access journal from MDPI · 2024Article
- Cryopreservation of ram semen: baicalein efficiency on oxidative stress, chromatin integrity, viability and motility post thaw.Frontiers in veterinary science · 2024Article
- Correlation between seminal plasma biochemical markers and semen parameters in idiopathic oligoasthenoteratospermia: identification of biomarkers for L-carnitine therapy.Frontiers in endocrinology · 2024Article
- The Potential Protective Role of Ascorbic Acid Against Testicular Toxicity Induced by Fluoxetine in Male Wistar Rats.Journal of experimental pharmacology · 2024Article
- Metabolomics Analysis of Sodium Salicylate Improving the Preservation Quality of Ram Sperm.Molecules (Basel, Switzerland) · 2023Article
- The Effect of Selenium Therapy on Semen Parameters, Antioxidant Capacity, and Sperm DNA Fragmentation in Men with Idiopathic Oligoasthenoteratospermia.Biological trace element research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress (OS) has been recognized as a significant cause of suboptimal assisted reproductive outcome. Many of the sperm preparation and manipulation procedures that are necessary in the in vitro environment can result in excessive production of reactive oxygen species (ROS) thereby exposing the gametes and growing embryos to significant oxidative damage. Antioxidants have long been utilized in the management of male subfertility as they can counterbalance the elevated levels of ROS inducing a high state of OS. Few studies have looked into the clinical effectiveness of antioxidants in patients undergoing assisted reproduction. While an overall favorable outcome has been perceived, the specific clinical indication and optimal antioxidant regimen remain unknown. The goal of our review is to explore the sources of ROS in the in vitro environment and provide a clinical scenario-based approach to identify the circumstances where antioxidant supplementation is most beneficial to enhance the outcome of assisted reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.